WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564793
Description: JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1.
MedKoo Cat#: 564793
Chemical Formula: C8H12N2O4
Exact Mass: 200.0797
Molecular Weight: 200.19
Elemental Analysis: C, 48.00; H, 6.04; N, 13.99; O, 31.97
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: JBP-485; JBP 485; JBP485; Cyclo-trans-4-L-hydroxyprolyl-L-serine
IUPAC/Chemical Name: (3S,7R,8aS)-Hexahydro-7-hydroxy-3-(hydroxymethyl)-pyrrolo[1,2-a]pyrazine-1,4-dione
InChi Key: FUYZNZHRVJWTLT-SRQIZXRXSA-N
InChi Code: InChI=1S/C8H12N2O4/c11-3-5-8(14)10-2-4(12)1-6(10)7(13)9-5/h4-6,11-12H,1-3H2,(H,9,13)/t4-,5+,6+/m1/s1
SMILES Code: O=C(N[C@H]1CO)[C@@](C[C@@H](O)C2)([H])N2C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 200.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Shu R, Wang C, Meng Q, Liu Z, Wu J, Sun P, Sun H, Ma X, Huo X, Liu K. Resveratrol enhances the protective effects of JBP485 against indomethacin-induced rat intestinal damage in vivo and vitro through up-regulating oligopeptide transporter 1 (Pept1). Biomed Pharmacother. 2018 Dec 23;111:251-261. doi: 10.1016/j.biopha.2018.12.084. [Epub ahead of print] PubMed PMID: 30590313.
2: Wen S, Wang C, Huo X, Meng Q, Liu Z, Yang S, Zhu Y, Sun H, Ma X, Liu K. JBP485 attenuates vancomycin-induced nephrotoxicity by regulating the expressions of organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp) in rats. Toxicol Lett. 2018 Oct 1;295:195-204. doi: 10.1016/j.toxlet.2018.06.1220. Epub 2018 Jun 28. PubMed PMID: 29964132.
3: Nagata M, Nakamura T, Hata Y, Yamaguchi S, Kaku T, Kinoshita S. JBP485 promotes corneal epithelial wound healing. Sci Rep. 2015 Oct 1;5:14776. doi: 10.1038/srep14776. PubMed PMID: 26424376; PubMed Central PMCID: PMC4589775.
4: Nakamura T, Hata Y, Nagata M, Yokoi N, Yamaguchi S, Kaku T, Kinoshita S. JBP485 promotes tear and mucin secretion in ocular surface epithelia. Sci Rep. 2015 May 21;5:10248. doi: 10.1038/srep10248. PubMed PMID: 25996902; PubMed Central PMCID: PMC4440520.
5: Guo X, Meng Q, Liu Q, Wang C, Huo X, Zhang Z, Kaku T, Liu K. Simultaneous determination of three dipeptides (JBP485, Gly-Sar and JBP923) in the cell lysates by liquid chromatography-tandem mass spectrometry: application to identify the function of the PEPT1 transfected cell. Biomed Chromatogr. 2014 Dec;28(12):1839-45. doi: 10.1002/bmc.3228. Epub 2014 Jun 6. PubMed PMID: 24903899.