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MedKoo CAT#: 564775

CAS#: 343307-76-6

Description: L48H37 is a specific myeloid differentiation 2 (MD2) inhibitor.

Price and Availability

Size Price Shipping out time Quantity
5mg USD 270 2 Weeks
25mg USD 650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-03-30. Prices are subject to change without notice.

L48H37, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data, and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 564775
Name: L48H37
CAS#: 343307-76-6
Chemical Formula: C27H33NO7
Exact Mass: 483.2257
Molecular Weight: 483.56
Elemental Analysis: C, 67.06; H, 6.88; N, 2.90; O, 23.16

Synonym: L48-H37; L48 H37; L48H37

IUPAC/Chemical Name: 1-Ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one


InChi Code: InChI=1S/C27H33NO7/c1-8-28-15-19(9-17-11-21(30-2)26(34-6)22(12-17)31-3)25(29)20(16-28)10-18-13-23(32-4)27(35-7)24(14-18)33-5/h9-14H,8,15-16H2,1-7H3/b19-9+,20-10+


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Correction to "Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2". J Pharmacol Exp Ther. 2018 Apr;365(1):201. doi: 10.1124/jpet.117.222570err. PubMed PMID: 29559582.

2: Feng C, Xia Y, Zou P, Shen M, Hu J, Ying S, Pan J, Liu Z, Dai X, Zhuge W, Liang G, Ruan Y. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777. doi: 10.1002/mc.22633. Epub 2017 Mar 10. PubMed PMID: 28218464.

3: Wang Y, Shan X, Dai Y, Jiang L, Chen G, Zhang Y, Wang Z, Dong L, Wu J, Guo G, Liang G. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50. doi: 10.1124/jpet.115.222570. Epub 2015 Apr 10. Erratum in: J Pharmacol Exp Ther. 2018 Apr;365(1):201. PubMed PMID: 25862641.