MY 5445
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584765

CAS#: 78351-75-4

Description: MY 5445 is a potential platelet aggregation inhibitor.


Price and Availability

Size
Price

10mg
USD 325
Size
Price

50mg
USD 985
Size
Price

MY 5445, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584765
Name: MY 5445
CAS#: 78351-75-4
Chemical Formula: C20H14ClN3
Exact Mass: 331.0876
Molecular Weight: 331.803
Elemental Analysis: C, 72.40; H, 4.25; Cl, 10.68; N, 12.66


Synonym: MY 5445; MY5445; MY-5445

IUPAC/Chemical Name: 1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-

InChi Key: CEHQLKSLMFIHBF-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)

SMILES Code: ClC1=CC(NC2=NN=C(C3=CC=CC=C3)C4=C2C=CC=C4)=CC=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Souness JE, Brazdil R, Diocee BK, Jordan R. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine. Br J Pharmacol. 1989 Nov;98(3):725-34. PubMed PMID: 2480168; PubMed Central PMCID: PMC1854783.

2: Zurbonsen K, Michel A, Vittet D, Bonnet PA, Chevillard C. Dissociation between phosphodiesterase inhibition and antiproliferative effects of phosphodiesterase inhibitors on the Dami cell line. Biochem Pharmacol. 1997 Apr 25;53(8):1141-7. PubMed PMID: 9175719.

3: Duarte ID, Ferreira SH. L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway. Mediators Inflamm. 2000;9(1):25-30. PubMed PMID: 10877451; PubMed Central PMCID: PMC1781740.

4: Ito M, Nishikawa M, Fujioka M, Miyahara M, Isaka N, Shiku H, Nakano T. Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021. Cell Signal. 1996 Dec;8(8):575-81. PubMed PMID: 9115850.

5: Duarte ID, Ferreira SH. The molecular mechanism of central analgesia induced by morphine or carbachol and the L-arginine-nitric oxide-cGMP pathway. Eur J Pharmacol. 1992 Oct 6;221(1):171-4. PubMed PMID: 1333972.

6: Messina E, Lupi F, Barile L, Giacomello A. Cyclic nucleotides and neuroblastoma differentiation. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1551-4. PubMed PMID: 15571296.

7: Radomski MW, Palmer RM, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1482-9. PubMed PMID: 2825688.

8: Ferreira SH, Duarte ID, Lorenzetti BB. The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release. Eur J Pharmacol. 1991 Aug 16;201(1):121-2. PubMed PMID: 1665419.

9: Wu CC, Ko FN, Kuo SC, Lee FY, Teng CM. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br J Pharmacol. 1995 Oct;116(3):1973-8. PubMed PMID: 8640334; PubMed Central PMCID: PMC1908948.

10: Petritsch C, Woscholski R, Edelmann HM, Ballou LM. Activation of p70 S6 kinase and erk-encoded mitogen-activated protein kinases is resistant to high cyclic nucleotide levels in Swiss 3T3 fibroblasts. J Biol Chem. 1995 Nov 3;270(44):26619-25. PubMed PMID: 7592886.

11: Duarte ID, dos Santos IR, Lorenzetti BB, Ferreira SH. Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway. Eur J Pharmacol. 1992 Jul 7;217(2-3):225-7. PubMed PMID: 1330593.

12: Ferreira SH, Duarte ID, Lorenzetti BB. Molecular base of acetylcholine and morphine analgesia. Agents Actions Suppl. 1991;32:101-6. PubMed PMID: 1676874.

13: Akamatsu N, Inenaga K, Yamashita H. Inhibitory effects of natriuretic peptides on vasopressin neurons mediated through cGMP and cGMP-dependent protein kinase in vitro. J Neuroendocrinol. 1993 Oct;5(5):517-22. PubMed PMID: 8680419.

14: Lanza F, Beretz A, Stierlé A, Corre G, Cazenave JP. Cyclic nucleotide phosphodiesterase inhibitors prevent aggregation of human platelets by raising cyclic AMP and reducing cytoplasmic free calcium mobilization. Thromb Res. 1987 Mar 1;45(5):477-84. PubMed PMID: 3035738.