BSJ-03-123
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MedKoo CAT#: 407956

CAS#: Unknown

Description: BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 6650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-07. Prices are subject to change without notice.

BSJ-03-123 purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407956
Name: BSJ-03-123
CAS#: Unknown
Chemical Formula: C48H57N9O11
Exact Mass: 935.4178
Molecular Weight: 936.036
Elemental Analysis: C, 61.59; H, 6.14; N, 13.47; O, 18.80


Synonym: BSJ-03-123; BSJ03-123; BSJ 03-123; BSJ-03123; BSJ03123; BSJ 03123;

IUPAC/Chemical Name: N-(2-(2-(2-(2-(4-(6-((3-acetyl-1-cyclopentyl-4-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

InChi Key: PHXAASMYZCBYHV-UHFFFAOYSA-N

InChi Code: InChI=1S/C48H57N9O11/c1-30-35-28-51-40(26-37(35)56(32-6-3-4-7-32)47(63)43(30)31(2)58)52-39-12-10-33(27-50-39)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-49-42(60)29-68-38-9-5-8-34-44(38)48(64)57(46(34)62)36-11-13-41(59)53-45(36)61/h5,8-10,12,26-28,32,36H,3-4,6-7,11,13-25,29H2,1-2H3,(H,49,60)(H,50,51,52)(H,53,59,61)

SMILES Code: O=C(NCCOCCOCCOCCN1CCN(C2=CC=C(NC3=CC4=C(C=N3)C(C)=C(C(C)=O)C(N4C5CCCC5)=O)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC,
Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Cell Chem Biol. 2018 Nov 22. pii: S2451-9456(18)30413-6. doi:
10.1016/j.chembiol.2018.11.006. [Epub ahead of print] PubMed PMID: 30595531.