L6Y

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564756

CAS#: 881290-53-5

Description: L6Y is a transthyretin (TTR) stabilizer which binds to the T4 binding pocket of TTR and prevents the dissociation of TTR to monomer.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-03-29. Prices are subject to change without notice.

L6Y is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564756
Name: L6Y
CAS#: 881290-53-5
Chemical Formula: C19H11NO4
Exact Mass: 317.0688
Molecular Weight: 317.3
Elemental Analysis: C, 71.92; H, 3.49; N, 4.41; O, 20.17


Synonym: L6Y; TTR stabilizer L6

IUPAC/Chemical Name: 6-Benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione

InChi Key: AFGMHSZWGJYWFH-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H11NO4/c21-17(11-5-2-1-3-6-11)13-9-10-15-16-12(13)7-4-8-14(16)18(22)20(24)19(15)23/h1-10,24H

SMILES Code: O=C1N(O)C(C2=CC=C(C(C3=CC=CC=C3)=O)C4=CC=CC1=C24)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Yokoyama T, Takaki S, Chosa K, Sato T, Suico MA, Teranishi Y, Shuto T, Mizuguchi M, Kai H. Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione. J Pharmacol Sci. 2015 Dec;129(4):240-3. doi: 10.1016/j.jphs.2015.09.006. Epub 2015 Nov 17. PubMed PMID: 26639444.