BAY-885

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MedKoo CAT#: 207081

CAS#: Unknown

Description: BAY-885 is a potent and selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-20. Prices are subject to change without notice.

BAY-885 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 207081
Name: BAY-885
CAS#: Unknown
Chemical Formula: C25H28F3N7O2
Exact Mass: 515.2257
Molecular Weight: 515.5412
Elemental Analysis: C, 58.24; H, 5.47; F, 11.06; N, 19.02; O, 6.21


Synonym: BAY-885; BAY 885; BAY885;

IUPAC/Chemical Name: (2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone

InChi Key: QXURFIGBRGWPQD-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28F3N7O2/c1-33-8-10-34(11-9-33)17-12-21-23(30-14-17)22(32-15-31-21)16-4-6-35(7-5-16)24(36)19-3-2-18(13-20(19)29)37-25(26,27)28/h2-3,12-16H,4-11,29H2,1H3

SMILES Code: O=C(C1=CC=C(OC(F)(F)F)C=C1N)N2CCC(C3=C4C(C=C(N5CCN(C)CC5)C=N4)=NC=N3)CC2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

ERK5 is a key integrator of cellular signal transduction, and it has been shown to play a role in various cellular processes such as proliferation, differentiation, apoptosis, and cell survival. Several studies have demonstrated that silencing ERK5 with siRNA or shRNA decreases the proliferation and increases cell death in different tumor models, thereby highlighting the potential of ERK5 as a therapeutic target in cancer.


References

Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2-d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5
Duy Nguyen, Clara Lemos, Lars Wortmann, Knut Eis, Simon J. Holton, Ulf Boemer, Dieter Moosmayer, Uwe Eberspaecher, Joerg Weiske, Christian Lechner, Stefan Prechtl, Detlev Suelzle, Franziska Siegel, Florian Prinz, Ralf Lesche, Barbara Nicke, Katrin Nowak-Reppel, Herbert Himmel, Dominik Mumberg, Franz von Nussbaum, Carl F. Nising, Marcus Bauser, and Andrea Haegebarth
J. Med. Chem., 2019, 62 (2), pp 928–940
Publication Date (Web): December 18, 2018 (Article)
DOI: 10.1021/acs.jmedchem.8b01606