Parbendazole free base
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MedKoo CAT#: 330168

CAS#: 14255-87-9 (free base)

Description: Parbendazole is an anthelmintic drug. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin and exhibits a broad-spectrum anthelmintic activity.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 350 2 Weeks
200mg USD 650 2 Weeks
500mg USD 1450 2 Weeks
1g USD 2250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Parbendazole free base, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 330168
Name: Parbendazole free base
CAS#: 14255-87-9 (free base)
Chemical Formula: C13H17N3O2
Exact Mass: 247.1321
Molecular Weight: 247.298
Elemental Analysis: C, 63.14; H, 6.93; N, 16.99; O, 12.94


Related CAS #: 14255-87-9 (free base)   83601-81-4 (HCl)    

Synonym: Parbendazole; PBZ; PBZ (fungicide); Helatac; Helmatac; SKF 29044; SKF-29044; SKF29044;

IUPAC/Chemical Name: N-(6-Butyl-1H-benzimidazol-2-yl)carbamic Acid Methyl Ester

InChi Key: YRWLZFXJFBZBEY-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17)

SMILES Code: O=C(OC)NC1=NC2=CC=C(CCCC)C=C2N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Brum AM, van de Peppel J, van der Leije CS, Schreuders-Koedam M, Eijken M, van der Eerden BC, van Leeuwen JP. Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12711-6. doi: 10.1073/pnas.1501597112. Epub 2015 Sep 29. PubMed PMID: 26420877; PubMed Central PMCID: PMC4611615.

2: Al-Hadiya BM. Parbendazole. Profiles Drug Subst Excip Relat Methodol. 2010;35:263-84. doi: 10.1016/S1871-5125(10)35005-9. Epub 2010 Mar 15. PubMed PMID: 22469223.

3: Hennessy DR, Steel JW, Prichard RK, Lacey E. The effect of co-administration of parbendazole on the disposition of oxfendazole in sheep. J Vet Pharmacol Ther. 1992 Mar;15(1):10-8. PubMed PMID: 1573698.

4: Sharma RK, Singh K, Saxena KK. The effect of piperazine adipate and parbendazole on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae. Angew Parasitol. 1987 Dec;28(4):207-10. PubMed PMID: 3445963.

5: Sharma RK, Singh K, Saxena KK. Effect of parbendazole and piperazine adipate on the activity of some enzymes of Ascaridia galli and Heterakis gallinae. Vet Parasitol. 1987 May;24(3-4):211-20. PubMed PMID: 3617427.

6: Hennessy DR, Steel JW, Dash KM, Lisle KA, Pearson IG. Potentiation by parbendazole of the anthelmintic activity of oxfendazole against natural infections of benzimidazole resistant nematodes. Aust Vet J. 1987 Jan;64(1):28-9. PubMed PMID: 3593136.

7: Wildgoose CL, Steele CE. In vitro teratogenicity of parbendazole. Arch Toxicol Suppl. 1987;11:172-4. PubMed PMID: 3477162.

8: Hennessy DR, Lacey E, Prichard RK, Steel JW. Potentiation of the anthelmintic activity of oxfendazole by parbendazole. J Vet Pharmacol Ther. 1985 Sep;8(3):270-5. PubMed PMID: 3840535.

9: Prozesky L, Joubert JP, Ekron MD. Paralysis in lambs caused by overdosing with parbendazole. Onderstepoort J Vet Res. 1981 Sep;48(3):159-67. PubMed PMID: 6895936.

10: Havercroft JC, Quinlan RA, Gull K. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204. PubMed PMID: 7031071.

11: Pereverzeva EV, Veretennikova NL, Ozeretskovskaia NN. [The effect of fenbendazole and parbendazole on the course of experimental trichinelliasis in white mice]. Med Parazitol (Mosk). 1981 Mar-Apr;50(2):46-50. Russian. PubMed PMID: 6894480.

12: Quinlan RA, Roobol A, Pogson CI, Gull K. A correlation between in vivo and in vitro effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on myxamoebae of Physarum polycephalum. J Gen Microbiol. 1981 Jan;122(1):1-6. PubMed PMID: 6895648.

13: Cruthers LR, James TM, Goff S. Efficacy of a tribromosalan and parbendazole composition against adult Fasciola hepatica in sheep. Res Vet Sci. 1981 Jan;30(1):122-3. PubMed PMID: 6894647.

14: Lyons ET, Drudge JH, Tolliver SC. Antiparasitic activity of parbendazole in critical tests in horses. Am J Vet Res. 1980 Jan;41(1):123-4. PubMed PMID: 6892671.

15: Varshney TR, Singh YP. A comparative sutdy of anthelmintic effect of naphthalophos and parbendazole against natural infection of gastro-intestinal worms of sheep. Indian Vet J. 1979 Mar;56(3):207-10. PubMed PMID: 582588.

16: Mercier-Parot L. [The teratogenic action of parbendazole]. Therapie. 1976 Jul-Aug;31(4):491-503. French. PubMed PMID: 1036798.

17: Delatour P, Lorgue G, Lapras M, Richard Y. [Embryotoxic and antimitotic properties of parbendazole, mebendazole and cambendazole]. C R Acad Sci Hebd Seances Acad Sci D. 1976 Feb 2;282(5):517-8. French. PubMed PMID: 817814.

18: Verberne LR, Mirck MH. [Concerning the toxicity of parbendazole (Helmatac 30) to horses and ponies (author's transl)]. Tijdschr Diergeneeskd. 1975 Nov 1;100(21):1143-52. Dutch. PubMed PMID: 1242825.

19: DiCuollo CJ, Miller JA, Mendelson WL, Pagano JF. Metabolic and tissue residue studies on parbendazole in sheep. J Agric Food Chem. 1974 Nov-Dec;22(6):948-53. PubMed PMID: 4430805.

20: Borgsteede FH. [Activity of parbendazole against gastro-intestinal nematodes in calves (author's transl)]. Tijdschr Diergeneeskd. 1974 Oct 1;99(19):991-5. Dutch. PubMed PMID: 4408472.