P 34081

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584751

CAS#: 148504-23-8

Description: P 34081 rapidly blocks parasite cysteine proteinase activity in vivo.


Price and Availability

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P 34081 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584751
Name: P 34081
CAS#: 148504-23-8
Chemical Formula: C26H33FN4O4
Exact Mass: 484.2486
Molecular Weight: 484.5724
Elemental Analysis: C, 64.45; H, 6.86; F, 3.92; N, 11.56; O, 13.21


Synonym: P 34081; P-34081; P34081

IUPAC/Chemical Name: Benzenepropanamide, N-(3-fluoro-2-oxo-1-(2-phenylethyl)propyl)-alpha-((((4-morpholinylmethyl)amino)carbonyl)amino)-, (S-(R*,R*))-

InChi Key: HVNUJYRAMGSGJV-GOTSBHOMSA-N

InChi Code: InChI=1S/C26H33FN4O4/c27-18-24(32)22(12-11-20-7-3-1-4-8-20)29-25(33)23(17-21-9-5-2-6-10-21)30-26(34)28-19-31-13-15-35-16-14-31/h1-10,22-23H,11-19H2,(H,29,33)(H2,28,30,34)/t22-,23-/m0/s1

SMILES Code: O=C(N[C@@H](CCC1=CC=CC=C1)C(CF)=O)[C@@H](NC(NCN2CCOCC2)=O)CC3=CC=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Perche O, Doly M, Ranchon-Cole I. Calpains are activated by light but their inhibition has no neuroprotective effect against light-damage. Exp Eye Res. 2009 Dec;89(6):989-94. doi: 10.1016/j.exer.2009.08.012. Epub 2009 Sep 1. PubMed PMID: 19729009.

2: Esser RE, Angelo RA, Murphey MD, Watts LM, Thornburg LP, Palmer JT, Talhouk JW, Smith RE. Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis. Arthritis Rheum. 1994 Feb;37(2):236-47. PubMed PMID: 8129779.

3: Rosenthal PJ, Lee GK, Smith RE. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J Clin Invest. 1993 Mar;91(3):1052-6. PubMed PMID: 8450035; PubMed Central PMCID: PMC288059.