Heptaminol hydrochloride
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MedKoo CAT#: 573259

CAS#: 543-15-7 (HCl)

Description: Heptaminol hydrochloride is an amino alcohol used as a myocardial stimulant, vasodilator, and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.


Chemical Structure

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Heptaminol hydrochloride
CAS# 543-15-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 573259
Name: Heptaminol hydrochloride
CAS#: 543-15-7 (HCl)
Chemical Formula: C8H20ClNO
Exact Mass: 181.12
Molecular Weight: 181.700
Elemental Analysis: C, 52.88; H, 11.09; Cl, 19.51; N, 7.71; O, 8.80

Price and Availability

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100mg USD 365 2 Weeks
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Related CAS #: 372-66-7 (free base)   543-15-7 (HCl)  

Synonym: Arcor tropfen, Cardiosintol, Corasor, Coreptil, Cortensor, Delmiton, EA-85, Heptaminol HCl, Heptaminol hydrochloride, Respirin

IUPAC/Chemical Name: 2-Heptanol, 6-amino-2-methyl-, hydrochloride

InChi Key: JZNBMCOSOXIZJB-UHFFFAOYSA-N

InChi Code: 1S/C8H19NO.ClH/c1-7(9)5-4-6-8(2,3)10;/h7,10H,4-6,9H2,1-3H3;1H

SMILES Code: Cl.CC(N)CCCC(C)(C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 181.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Drugs for hypotension: disproportionate harms with etilefrine and heptaminol. . Prescrire Int. 2015 Jul;24(162):184. PubMed PMID: 26240886.

2: Bahloul M, Chaari A, Ben Mbarek MN, Kallel H, Bouaziz M. Use of heptaminol hydrochloride for catecholamine weaning in septic shock. Am J Ther. 2012 Jan;19(1):e8-17. doi: 10.1097/MJT.0b013e3181e9b630. PubMed PMID: 20720484.

3: GARRETT J. [Pharmacodynamic study of 6-amino-2-methyl-2-heptanol hydrochloride (heptaminol hydrochloride or R. P. 2831). I. Action of heptaminol hydrochloride on the cardiovascular and central nervous systems]. Arch Int Pharmacodyn Ther. 1954 Nov 1;100(1):17-34. French. PubMed PMID: 14350831.