WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 207077
CAS#: 2239273-34-6
Description: Etrumadenant, also known as AB928, is a dual antagonist of the A2aR and A2bR adenosine receptors, leads to greater immune activation and reduced tumor growth when combined with chemotherapy
MedKoo Cat#: 207077
Name: Etrumadenant
CAS#: 2239273-34-6
Chemical Formula: C23H22N8O
Exact Mass: 426.1917
Molecular Weight: 426.484
Elemental Analysis: C, 64.77; H, 5.20; N, 26.27; O, 3.75
Synonym: AB928 ; AB-928; AB 928; etrumadenant
IUPAC/Chemical Name: 3-[2-Amino-6-[1-[[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl]triazol-4-yl]pyrimidin-4-yl]-2-methylbenzonitrile
InChi Key: BUXIAWLTBSXYSW-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H22N8O/c1-14-15(11-24)6-4-8-17(14)18-10-19(28-22(25)27-18)20-13-31(30-29-20)12-16-7-5-9-21(26-16)23(2,3)32/h4-10,13,32H,12H2,1-3H3,(H2,25,27,28)
SMILES Code: N#CC1=CC=CC(C2=NC(N)=NC(C3=CN(CC4=NC(C(C)(O)C)=CC=C4)N=N3)=C2)=C1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 426.484 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Preparation of azolopyrimidine for the treatment of cancer and immune related disorders
By Beatty, Joel; Debien, Laurent; Jeffrey, Jenna; Leleti, Manmohan Reddy; Mandal, Debashis; Miles, Dillon; Powers, Jay; Rosen, Brandon; Thomas-Tran, Rhiannon; Sharif, Ehesan. From PCT Int. Appl. (2018), WO 2018136700 A1 20180726.
The structure of AR928 was from below web pages:
https://pubchem.ncbi.nlm.nih.gov/compound/135242184
https://chem.nlm.nih.gov/chemidplus/sid/2239273346
