JNJ-63576253
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MedKoo CAT#: 207041

CAS#: 2110426-27-0 (free base)

Description: TRC253, also known as JNJ63576253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.


Chemical Structure

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JNJ-63576253
CAS# 2110426-27-0 (free base)

Theoretical Analysis

MedKoo Cat#: 207041
Name: JNJ-63576253
CAS#: 2110426-27-0 (free base)
Chemical Formula: C23H21F3N6O2S
Exact Mass: 502.1399
Molecular Weight: 502.5162
Elemental Analysis: C, 54.97; H, 4.21; F, 11.34; N, 16.72; O, 6.37; S, 6.38

Price and Availability

Size Price Availability Quantity
10.0mg USD 160.0 2 Weeks
25.0mg USD 350.0 2 Weeks
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1450.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3750.0 2 Weeks
2.0g USD 6250.0 2 Weeks
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Related CAS #: 2110428-64-1 (HCl)   2110426-27-0 (free base)    

Synonym: TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253;

IUPAC/Chemical Name: 5-(8-Oxo-5-(6-(piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)-picolinonitrile

InChi Key: OUEHJEYKNYQVRC-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H21F3N6O2S/c24-23(25,26)17-10-15(13-29-18(17)11-27)31-20(33)22(6-1-7-22)32(21(31)35)14-2-3-19(30-12-14)34-16-4-8-28-9-5-16/h2-3,10,12-13,16,28H,1,4-9H2

SMILES Code: N#CC1=NC=C(N(C2=O)C(N(C3=CC=C(OC4CCNCC4)N=C3)C52CCC5)=S)C=C1C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 502.5162 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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