Lysine-iodoacetylmethotrexate

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530770

CAS#: 82339-36-4

Description: Lysine-iodoacetylmethotrexate if a Folic Acid Antagonist.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-11-29. Prices are subject to change without notice.

Lysine-iodoacetylmethotrexate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530770
Name: Lysine-iodoacetylmethotrexate
CAS#: 82339-36-4
Chemical Formula: C23H28IN9O4
Exact Mass: 621.1309
Molecular Weight: 621.4405
Elemental Analysis: C, 44.45; H, 4.54; I, 20.42; N, 20.29; O, 10.30


Synonym: Lysine-iodoacetylmethotrexate

IUPAC/Chemical Name: L-Lysine, N2-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-N6-(iodoacetyl)-

InChi Key: NDRPUTRIAJPVPS-INIZCTEOSA-N

InChi Code: InChI=1S/C23H28IN9O4/c1-33(12-14-11-28-20-18(29-14)19(25)31-23(26)32-20)15-7-5-13(6-8-15)21(35)30-16(22(36)37)4-2-3-9-27-17(34)10-24/h5-8,11,16H,2-4,9-10,12H2,1H3,(H,27,34)(H,30,35)(H,36,37)(H4,25,26,28,31,32)/t16-/m0/s1

SMILES Code: O=C(O)[C@H](CCCCNC(CI)=O)NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Rosowsky A, Wright JE, Ginty C, Uren J. Methotrexate analogues. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase. J Med Chem. 1982 Aug;25(8):960-4. PubMed PMID: 6811744.