Lysine alpha-ketoisovalerate

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MedKoo CAT#: 530767

CAS#: 78000-30-3

Description: Lysine alpha-ketoisovalerate is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-12-05. Prices are subject to change without notice.

Lysine alpha-ketoisovalerate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530767
Name: Lysine alpha-ketoisovalerate
CAS#: 78000-30-3
Chemical Formula: C11H22N2O5
Exact Mass: 262.1529
Molecular Weight: 262.306
Elemental Analysis: C, 50.37; H, 8.45; N, 10.68; O, 30.50


Synonym: Lysine alpha-ketoisovalerate

IUPAC/Chemical Name: L-Lysine mono(3-methyl-2-oxobutyrate)

InChi Key: VRFAQQYAKWMFLR-JEDNCBNOSA-N

InChi Code: InChI=1S/C6H14N2O2.C5H8O3/c7-4-2-1-3-5(8)6(9)10;1-3(2)4(6)5(7)8/h5H,1-4,7-8H2,(H,9,10);3H,1-2H3,(H,7,8)/t5-;/m0./s1

SMILES Code: N[C@@H](CCCCN)C(O)=O.CC(C)C(C(O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Buchholz J, Schwentner A, Brunnenkan B, Gabris C, Grimm S, Gerstmeir R, Takors R, Eikmanns BJ, Blombach B. Platform engineering of Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improved production of L-lysine, L-valine, and 2-ketoisovalerate. Appl Environ Microbiol. 2013 Sep;79(18):5566-75. doi: 10.1128/AEM.01741-13. Epub 2013 Jul 8. PubMed PMID: 23835179; PubMed Central PMCID: PMC3754147.

2: Aevarsson A, Seger K, Turley S, Sokatch JR, Hol WG. Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. Nat Struct Biol. 1999 Aug;6(8):785-92. PubMed PMID: 10426958.

3: Ro HS, Hong SP, Seo HJ, Yoshimura T, Esaki N, Soda K, Kim HS, Sung MH. Site-directed mutagenesis of the amino acid residues in beta-strand III [Val30-Val36] of D-amino acid aminotransferase of Bacillus sp. YM-1. FEBS Lett. 1996 Dec 2;398(2-3):141-5. PubMed PMID: 8977094.

4: Hu H, Jaskiewicz JA, Harris RA. Ethanol and oleate inhibition of alpha-ketoisovalerate and 3-hydroxyisobutyrate metabolism by isolated hepatocytes. Arch Biochem Biophys. 1992 Nov 15;299(1):57-62. PubMed PMID: 1444452.

5: Nair KS, Schwartz RG, Welle S. Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. Am J Physiol. 1992 Nov;263(5 Pt 1):E928-34. PubMed PMID: 1443126.

6: Funk MA, Lowry KR, Baker DH. Utilization of the L- and DL-isomers of alpha-keto-beta-methylvaleric acid by rats and comparative efficacy of the keto analogs of branched-chain amino acids provided as ornithine, lysine and histidine salts. J Nutr. 1987 Sep;117(9):1550-5. PubMed PMID: 3116181.