Lysine hydroxamate

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MedKoo CAT#: 530752

CAS#: 25125-92-2

Description: Lysine hydroxamate is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-12-05. Prices are subject to change without notice.

Lysine hydroxamate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530752
Name: Lysine hydroxamate
CAS#: 25125-92-2
Chemical Formula: C6H15N3O2
Exact Mass: 161.1164
Molecular Weight: 161.205
Elemental Analysis: C, 44.70; H, 9.38; N, 26.07; O, 19.85


Synonym: Lysine hydroxamate

IUPAC/Chemical Name: Hexanamide, 2,6-diamino-N-hydroxy-, (S)-

InChi Key: NZWPVDFOIUKVSJ-YFKPBYRVSA-N

InChi Code: InChI=1S/C6H15N3O2/c7-4-2-1-3-5(8)6(10)9-11/h5,11H,1-4,7-8H2,(H,9,10)/t5-/m0/s1

SMILES Code: O=C(NO)[C@@H](N)CCCCN


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Sakurama H, Takita T, Mikami B, Itoh T, Yasukawa K, Inouye K. Two crystal structures of lysyl-tRNA synthetase from Bacillus stearothermophilus in complex with lysyladenylate-like compounds: insights into the irreversible formation of the enzyme-bound adenylate of L-lysine hydroxamate. J Biochem. 2009 May;145(5):555-63. doi: 10.1093/jb/mvp014. Epub 2009 Jan 27. PubMed PMID: 19174549.

2: Wirgau JI, Spasojević I, Boukhalfa H, Batinić-Haberle I, Crumbliss AL. Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid. Inorg Chem. 2002 Mar 25;41(6):1464-73. PubMed PMID: 11896715.

3: Takita T, Akita E, Inouye K, Tonomura B. Lysyl-tRNA synthetase from Bacillus stearothermophilus. Stopped-flow kinetic analysis of enzyme.lysyladenylate formation. J Biochem. 1998 Jul;124(1):45-50. PubMed PMID: 9644244.

4: Kyriacou A, Balis C, Typas MA. Improvement of lysine production by analog-sensitive and auxotroph mutants of the acetylene-utilizing bacterium Gordona bronchialis (Rhodococcus bronchialis). Appl Biochem Biotechnol. 1997 Jun;66(3):281-9. PubMed PMID: 9276926.

5: Takita T, Hashimoto S, Ohkubo Y, Muto T, Shimizu N, Sukata T, Inouye K, Hiromi K, Tonomura B. Lysyl-tRNA synthetase from Bacillus stearothermophilus. Formation and isolation of an enzyme-lysyladenylate complex and its analogue. J Biochem. 1997 Feb;121(2):244-50. PubMed PMID: 9089397.

6: Barak Z, Lindsley D, Gallant J. On the mechanism of leftward frameshifting at several hungry codons. J Mol Biol. 1996 Mar 8;256(4):676-84. PubMed PMID: 8642590.

7: al-Swayeh OA, Moore PK. Amino acids dilate resistance blood vessels of the perfused rat mesentery. J Pharm Pharmacol. 1989 Oct;41(10):723-6. PubMed PMID: 2575155.

8: Lunts MG, Gusiatiner MM, Kopteva AV, Zhdanova NI. [Characteristics of lysine transport in a wild type strain and lysine-producing mutant of Corynebacterium glutamicum]. Prikl Biokhim Mikrobiol. 1986 Jan-Feb;22(1):96-101. Russian. PubMed PMID: 3081884.

9: Hilderman RH, Zimmerman JK, Dang CV, Grothusen JR. Characterization of a homogeneous arginyl- and lysyl-tRNA synthetase complex isolated from rat liver. Kinetic mechanism for lysyl-tRNA synthetase. J Biol Chem. 1983 Nov 25;258(22):13592-6. PubMed PMID: 6315704.

10: Mehta RJ, Nash CH. Relationship between carbon source and susceptibility of Cephalosporium acremonium to selected amino acid analogues. Can J Microbiol. 1979 Jul;25(7):818-21. PubMed PMID: 573170.

11: Tosa T, Pizer LI. Effect of serine hydroxamate on the growth of Escherichia coli. J Bacteriol. 1971 Jun;106(3):966-71. PubMed PMID: 4934071; PubMed Central PMCID: PMC248739.