Lysine 4-nitroanilide

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530749

CAS#: 6184-11-8

Description: Lysine 4-nitroanilide is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-11-29. Prices are subject to change without notice.

Lysine 4-nitroanilide is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530749
Name: Lysine 4-nitroanilide
CAS#: 6184-11-8
Chemical Formula: C12H18N4O3
Exact Mass: 266.1379
Molecular Weight: 266.301
Elemental Analysis: C, 54.12; H, 6.81; N, 21.04; O, 18.02


Synonym: Lysine 4-nitroanilide

IUPAC/Chemical Name: Hexanamide, 2,6-diamino-N-(4-nitrophenyl)-

InChi Key: VUUNELJIFNFWJC-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H18N4O3/c13-8-2-1-3-11(14)12(17)15-9-4-6-10(7-5-9)16(18)19/h4-7,11H,1-3,8,13-14H2,(H,15,17)

SMILES Code: O=C(NC1=CC=C([N+]([O-])=O)C=C1)C(N)CCCCN


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Sousa MO, Miranda TL, Maia CN, Bittar ER, Santoro MM, Figueiredo AF. Kinetic peculiarities of human tissue kallikrein: 1--substrate activation in the catalyzed hydrolysis of H-D-valyl-L-leucyl-L-arginine 4-nitroanilide and H-D-valyl-L-leucyl-L-lysine 4-nitroanilide; 2--substrate inhibition in the catalyzed hydrolysis of N alpha-p-tosyl-L-arginine methyl ester. Arch Biochem Biophys. 2002 Apr 1;400(1):7-14. PubMed PMID: 11913965.

2: Stepanov VM, Terent'eva EYu, Voyushina TL, Gololobov MYu. Subtilisin and alpha-chymotrypsin catalyzed synthesis of peptides containing arginine and lysine p-nitroanilides as C-terminal moieties. Bioorg Med Chem. 1995 May;3(5):479-85. PubMed PMID: 7648197.

3: Blanc B, Laloi P, Atlan D, Gilbert C, Portalier R. Two cell-wall-associated aminopeptidases from Lactobacillus helveticus and the purification and characterization of APII from strain ITGL1. J Gen Microbiol. 1993 Jul;139(7):1441-8. PubMed PMID: 8371107.

4: Arbesú MJ, Valle E, Suárez-Rendueles P. Purification and characterization of aminopeptidase yspI from Schizosaccharomyces pombe. Yeast. 1993 Jun;9(6):637-44. PubMed PMID: 8346680.

5: Cowman RA, Baron SS. Studies on the subcellular localization of protease and arylaminopeptidase activities in Streptococcus sanguis ATCC 10556. J Dent Res. 1991 Dec;70(12):1508-15. PubMed PMID: 1774382.

6: Petersen LC, Brender J, Suenson E. Zymogen-activation kinetics. Modulatory effects of trans-4-(aminomethyl)cyclohexane-1-carboxylic acid and poly-D-lysine on plasminogen activation. Biochem J. 1985 Jan 1;225(1):149-58. PubMed PMID: 2579638; PubMed Central PMCID: PMC1144563.

7: Petersen LC, Clemmensen I. Kinetics of plasmin inhibition in the presence of a synthetic tripeptide substrate. The reaction with pancreatic trypsin inhibitor and two forms of alpha 2-plasmin inhibitor. Biochem J. 1981 Oct 1;199(1):121-7. PubMed PMID: 6175313; PubMed Central PMCID: PMC1163341.

8: Eggimann B, Bachmann M. Purification and Partial Characterization of an Aminopeptidase from Lactobacillus lactis. Appl Environ Microbiol. 1980 Nov;40(5):876-82. PubMed PMID: 16345655; PubMed Central PMCID: PMC291682.

9: Papke G, Blobel H. [Qualitative and quantitative determinations of staphylokinase-activity (author's transl)]. Zentralbl Bakteriol Orig A. 1978 Dec;242(4):456-61. German. PubMed PMID: 219637.

10: Bury AF, Coolbear T, Savery CR. Separation and properties of two arylamidases from rat cardiac-muscle extracts. Biochem J. 1977 Jun 1;163(3):565-70. PubMed PMID: 406901; PubMed Central PMCID: PMC1164737.