Lysergide maleate

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530736

CAS#: 24656-41-5

Description: Lysergide, also known as Lysergic acid diethylamide and LSD, is a hallucinogenic drug. Effects typically include altered thoughts, feelings, and awareness of one's surroundings. LSD binds to most serotonin receptor subtypes except for the 5-HT3 and 5-HT4 receptors. However, most of these receptors are affected at too low affinity to be sufficiently activated by the brain concentration of approximately 10–20 nM. In humans, recreational doses of LSD can affect 5-HT1A (Ki=1.1nM), 5-HT2A (Ki=2.9nM), 5-HT2B (Ki=4.9nM), 5-HT2C (Ki=23nM), 5-HT5A (Ki=9nM , and 5-HT6 receptors (Ki=2.3nM). 5-HT5B receptors, which are not present in humans, also have a high affinity for LSD. Lysergide maleate is discontinued (DEA controlled substance).


Price and Availability

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Pricing updated 2020-11-29. Prices are subject to change without notice.

Lysergide maleate is discontinued (DEA controlled substance).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530736
Name: Lysergide maleate
CAS#: 24656-41-5
Chemical Formula: C24H29N3O5
Exact Mass: 439.2107
Molecular Weight: 439.512
Elemental Analysis: C, 65.59; H, 6.65; N, 9.56; O, 18.20


Synonym: Lysergide maleate; Lysergic acid diethylamide; LSD, LSD-25, Acid, Delysid.

IUPAC/Chemical Name: Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)-, (Z)-2-butenedioate (1:1)

InChi Key: PBZHMSZIBQNTPH-ZYXUSYCASA-N

InChi Code: InChI=1S/C20H25N3O.C4H4O4/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14;5-3(6)1-2-4(7)8/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,18-;/m1./s1

SMILES Code: [H][C@@]1(N(C)C[C@H](C(N(CC)CC)=O)C=C12)CC3=CNC4=C3C2=CC=C4.O=C(O)/C=C\C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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2: Seeman P, Ko F, Tallerico T. Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics. Mol Psychiatry. 2005 Sep;10(9):877-83. PubMed PMID: 15852061.

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4: Tomitaka M, Tomitaka S, Rajdev S, Sharp FR. Fluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats. Biol Psychiatry. 2000 May 1;47(9):836-41. PubMed PMID: 10812043.

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6: Carter D, Champney M, Hwang B, Eglen RM. Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. Eur J Pharmacol. 1995 Jul 14;280(3):243-50. PubMed PMID: 8566092.

7: Carlsson ML. The selective 5-HT2A receptor antagonist MDL 100,907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse--implications for psychosis. J Neural Transm Gen Sect. 1995;100(3):225-37. PubMed PMID: 8748668.

8: Callahan PM, Appel JB. Differentiation between the stimulus effects of (+)-lysergic acid diethylamide and lisuride using a three-choice, drug discrimination procedure. Psychopharmacology (Berl). 1990;100(1):13-8. PubMed PMID: 2296621.

9: White FJ. Comparative effects of LSD and lisuride: clues to specific hallucinogenic drug actions. Pharmacol Biochem Behav. 1986 Feb;24(2):365-79. PubMed PMID: 3952127.

10: Minnema DJ, Hendry JS, Rosecrans JA. Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist. Psychopharmacology (Berl). 1984;83(2):200-4. PubMed PMID: 6431474.

11: Minnema DJ, Rosecrans JA. Amphetamine and LSD as discriminative stimuli: alterations following neonatal monoamine reductions. Pharmacol Biochem Behav. 1984 Jan;20(1):95-101. PubMed PMID: 6420809.

12: White FJ, Appel JB. The role of dopamine and serotonin in the discriminative stimulus effects of lisuride. J Pharmacol Exp Ther. 1982 May;221(2):421-7. PubMed PMID: 7077537.

13: Winter JC. Effects of the phenethylamine derivatives, BL-3912, fenfluramine, and Sch-12679, in rats trained with LSD as a discriminative stimulus. Psychopharmacology (Berl). 1980;68(2):159-62. PubMed PMID: 6776559.

14: Sondack DL. TLC separation and identification of diastereomers of D-ergonovine maleate. J Pharm Sci. 1974 Jul;63(7):1141-3. PubMed PMID: 4855292.

15: Boakes RJ, Bradley PB, Briggs I, Dray A. Antagonism of 5-hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25. Br J Pharmacol. 1970 Oct;40(2):202-18. PubMed PMID: 5492893; PubMed Central PMCID: PMC1702892.

16: Semonský M, Zikán V, Votava Z, Podvalová I, Ponec K. [N-(D-6-methyl-8-isoergolenyl)-N',N'-diethyl-urea acid maleate (Lysenyl Spofa--a new drug with antiserotonin action]. Cesk Farm. 1968 Jul;17(6):296-305. Review. Czech. PubMed PMID: 4972449.

17: OH JO, EVANS CA. Suppressive effects of pyrilamine maleate and d-lysergic acid diethylamide (LSD-25) on early corneal lesions produced in vitro by Newcastle disease virus (NDV) and compound 48/80. Virology. 1960 Jan;10:127-43. PubMed PMID: 14428440.