B 4148

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530715

CAS#: 103412-37-9

Description: B 4148 is a bradykinin inhibitor.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-12. Prices are subject to change without notice.

B 4148 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530715
Name: B 4148
CAS#: 103412-37-9
Chemical Formula: C62H95N19O14S2
Exact Mass: 1393.6747
Molecular Weight: 1394.681
Elemental Analysis: C, 53.39; H, 6.87; N, 19.08; O, 16.06; S, 4.60

Synonym: B 4148

IUPAC/Chemical Name: L-Arginine, N2-(N-(N-(N-(N-(N-(1-(trans-4-hydroxy-1-(N2-(N2-L-lysyl-L-lysyl)-L-arginyl)-L-prolyl)-L-prolyl)glycyl)-3-(2-thienyl)-L-alanyl)-L-seryl)-D-phenylalanyl)-3-(2-thienyl)-L-alanyl)-


InChi Code: InChI=1S/C62H95N19O14S2/c63-22-6-4-17-40(65)51(85)74-41(18-5-7-23-64)52(86)75-42(19-8-24-70-61(66)67)58(92)81-34-37(83)30-49(81)59(93)80-26-10-21-48(80)57(91)72-33-50(84)73-45(31-38-15-11-27-96-38)54(88)79-47(35-82)56(90)77-44(29-36-13-2-1-3-14-36)53(87)78-46(32-39-16-12-28-97-39)55(89)76-43(60(94)95)20-9-25-71-62(68)69/h1-3,11-16,27-28,37,40-49,82-83H,4-10,17-26,29-35,63-65H2,(H,72,91)(H,73,84)(H,74,85)(H,75,86)(H,76,89)(H,77,90)(H,78,87)(H,79,88)(H,94,95)(H4,66,67,70)(H4,68,69,71)/t37-,40+,41+,42+,43+,44-,45+,46+,47+,48+,49+/m1/s1

SMILES Code: N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC1=CC=CS1)NC([C@@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CC3=CC=CS3)NC(CNC([C@H]4N(C([C@H]5N(C([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)N)=O)=O)=O)C[C@H](O)C5)=O)CCC4)=O)=O)=O)=O)=O)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Weipert J, Hoffmann H, Siebeck M, Whalley ET. Endotoxin shock in the rat: reduction of arterial blood pressure fall by the bradykinin antagonist B4148. Prog Clin Biol Res. 1989;308:983-7. PubMed PMID: 2675079.

2: Weipert J, Hoffmann H, Siebeck M, Whalley ET. Attenuation of arterial blood pressure fall in endotoxin shock in the rat using the competitive bradykinin antagonist Lys-Lys-[Hyp2, Thi5,8, DPhe7]-Bk (B4148). Br J Pharmacol. 1988 Jun;94(2):282-4. PubMed PMID: 3395779; PubMed Central PMCID: PMC1853989.