Gemcabene

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564683

CAS#: 183293-82-5

Description: Gemcabene is a lipid altering agent which lowers low-density lipoprotein cholesterol (LDL-C) and decreases triglycerides. Gemcabene increases high density lipoprotein (HDL) cholesterol levels and HDL particle size.


Price and Availability

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Gemcabene is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564683
Name: Gemcabene
CAS#: 183293-82-5
Chemical Formula: C16H30O5
Exact Mass: 302.2093
Molecular Weight: 302.41
Elemental Analysis: C, 63.55; H, 10.00; O, 26.45


Synonym: PD72953; PD 72953; PD-72953; Gemcabene

IUPAC/Chemical Name: 6,6'-Oxybis(2,2-dimethylhexanoic acid)

InChi Key: SDMBRCRVFFHJKR-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H30O5/c1-15(2,13(17)18)9-5-7-11-21-12-8-6-10-16(3,4)14(19)20/h5-12H2,1-4H3,(H,17,18)(H,19,20)

SMILES Code: O=C(O)C(C)(C)CCCCOCCCCC(C)(C)C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Srivastava RAK, Cornicelli JA, Markham B, Bisgaier CL. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471. doi: 10.3389/fphar.2018.00471. eCollection 2018. PubMed PMID: 29867478; PubMed Central PMCID: PMC5958179.

2: Oniciu DC, Hashiguchi T, Shibazaki Y, Bisgaier CL. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13(5):e0194568. doi: 10.1371/journal.pone.0194568. eCollection 2018. PubMed PMID: 29847555; PubMed Central PMCID: PMC5976190.

3: Srivastava RAK, Cornicelli JA, Markham B, Bisgaier CL. Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism. Mol Cell Biochem. 2018 Dec;449(1-2):167-183. doi: 10.1007/s11010-018-3353-5. Epub 2018 Apr 11. PubMed PMID: 29644527; PubMed Central PMCID: PMC6223808.

4: Bisgaier CL, Oniciu DC, Srivastava RAK. Comparative Evaluation of Gemcabene and Peroxisome Proliferator-Activated Receptor Ligands in Transcriptional Assays of Peroxisome Proliferator-Activated Receptors: Implication for the Treatment of Hyperlipidemia and Cardiovascular Disease. J Cardiovasc Pharmacol. 2018 Jul;72(1):3-10. doi: 10.1097/FJC.0000000000000580. PubMed PMID: 29621036; PubMed Central PMCID: PMC6039382.