WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564678
CAS#: 2243076-67-5 (free base)
Description: ZXH-3-26 is a selective degrader of BRD4.
MedKoo Cat#: 564678
Name: ZXH-3-26
CAS#: 2243076-67-5 (free base)
Chemical Formula: C39H39ClN8O7S
Exact Mass: 798.2351
Molecular Weight: 799.3
Elemental Analysis: C, 58.60; H, 4.92; Cl, 4.44; N, 14.02; O, 14.01; S, 4.01
Related CAS #: 2243076-67-5 (free base) 2307475-86-9 (TFA) ZXH-3-26 HCl
Synonym: ZXH326; ZXH 326; ZXH-326; ZXH 3 26; ZXH-326; ZXH-3-26;
IUPAC/Chemical Name: Methyl 2-((6S)-4-(4-chlorophenyl)-2-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
InChi Key: KLLGWPDWPSUTCL-QBHOUYDASA-N
InChi Code: InChI=1S/C39H39ClN8O7S/c1-20-30-32(22-11-13-23(40)14-12-22)43-26(19-29(50)55-3)34-46-45-21(2)47(34)39(30)56-33(20)36(52)42-18-7-5-4-6-17-41-25-10-8-9-24-31(25)38(54)48(37(24)53)27-15-16-28(49)44-35(27)51/h8-14,26-27,41H,4-7,15-19H2,1-3H3,(H,42,52)(H,44,49,51)/t26-,27?/m0/s1
SMILES Code: O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 799.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
