WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564653

CAS#: 755002-90-5

Description: VU0134992 is a selective Kir4.1 potassium channel pore blocker.

Chemical Structure

CAS# 755002-90-5

Theoretical Analysis

MedKoo Cat#: 564653
Name: VU0134992
CAS#: 755002-90-5
Chemical Formula: C20H31BrN2O2
Exact Mass: 410.1569
Molecular Weight: 411.38
Elemental Analysis: C, 58.39; H, 7.60; Br, 19.42; N, 6.81; O, 7.78

Price and Availability

Size Price Availability Quantity
10.0mg USD 355.0 2 Weeks
50.0mg USD 1185.0 2 Weeks
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Synonym: VU-992; VU 992; VU992; VU-0134992; VU 0134992; VU0134992

IUPAC/Chemical Name: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide


InChi Code: InChI=1S/C20H31BrN2O2/c1-13(2)14-7-8-17(16(21)9-14)25-12-18(24)22-15-10-19(3,4)23-20(5,6)11-15/h7-9,13,15,23H,10-12H2,1-6H3,(H,22,24)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 411.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kharade SV, Kurata H, Bender AM, Blobaum AL, Figueroa EE, Duran A, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, Denton JS. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937. doi: 10.1124/mol.118.112359. Epub 2018 Jun 12. PubMed PMID: 29895592; PubMed Central PMCID: PMC6041953.