Uzansertib (INCB053914)
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MedKoo CAT#: 555386

CAS#: 1620012-39-6

Description: INCB053914, also known as Uzansertib, is a novel, potent, and selective adenosine triphosphate-competitive pan-PIM kinase inhibitor. In vitro, INCB053914 inhibited proliferation and the phosphorylation of downstream substrates in cell lines from multiple hematologic malignancies. INCB053914, may have therapeutic utility in hematologic malignancies when combined with other inhibitors of oncogenic kinases or standard chemotherapeutics.


Chemical Structure

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Uzansertib (INCB053914)
CAS# 1620012-39-6

Theoretical Analysis

MedKoo Cat#: 555386
Name: Uzansertib (INCB053914)
CAS#: 1620012-39-6
Chemical Formula: C26H26F3N5O3
Exact Mass: 513.1988
Molecular Weight: 513.5212
Elemental Analysis: C, 60.81; H, 5.10; F, 11.10; N, 13.64; O, 9.35

Price and Availability

Size Price Availability Quantity
5.0mg USD 350.0 2 Weeks
10.0mg USD 600.0 2 Weeks
25.0mg USD 1450.0 2 Weeks
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Synonym: INCB053914; INCB-053914; INCB 053914; INCB53914; INCB-53914; INCB 53914; Uzansertib

IUPAC/Chemical Name: N-((R)-4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

InChi Key: PTORCEYGCGXHDH-OVMXCRKPSA-N

InChi Code: InChI=1S/C26H26F3N5O3/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(H,33,37)/t12-,17+,20+,25+/m0/s1

SMILES Code: O=C(NC1=CN=C2C(CC[C@H]2O)=C1N3C[C@@H](N)[C@H](O)[C@@H](C)C3)C4=NC(C5=C(F)C=CC=C5F)=C(F)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 513.5212 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Koblish H, Li YL, Shin N, Hall L, Wang Q, Wang K, Covington M, Marando C,
Bowman K, Boer J, Burke K, Wynn R, Margulis A, Reuther GW, Lambert QT, Dostalik
Roman V, Zhang K, Feng H, Xue CB, Diamond S, Hollis G, Yeleswaram S, Yao W, Huber
R, Vaddi K, Scherle P. Preclinical characterization of INCB053914, a novel
pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in
models of hematologic malignancies. PLoS One. 2018 Jun 21;13(6):e0199108. doi:
10.1371/journal.pone.0199108. eCollection 2018. PubMed PMID: 29927999; PubMed
Central PMCID: PMC6013247.