WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564640
Description: D2923 is a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R).
MedKoo Cat#: 564640
Chemical Formula: C31H36Cl2N8O2
Exact Mass: 622.2338
Molecular Weight: 623.58
Elemental Analysis: C, 59.71; H, 5.82; Cl, 11.37; N, 17.97; O, 5.13
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: D-2923; D 2923; D2923
IUPAC/Chemical Name: (S)-3-(2,6-Dichlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(1-propionylpyrrolidin-3-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
InChi Key: UAEJGNXQHGHNAP-QHCPKHFHSA-N
InChi Code: InChI=1S/C31H36Cl2N8O2/c1-4-27(42)39-11-10-23(19-39)41-29-21(18-40(31(41)43)28-24(32)6-5-7-25(28)33)17-34-30(36-29)35-22-8-9-26(20(2)16-22)38-14-12-37(3)13-15-38/h5-9,16-17,23H,4,10-15,18-19H2,1-3H3,(H,34,35,36)/t23-/m0/s1
SMILES Code: O=C1N([C@@H]2CN(C(CC)=O)CC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)=NC=C3CN1C6=C(Cl)C=CC=C6Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 623.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Liu YQ, Wang YN, Lu XY, Tong LJ, Li Y, Zhang T, Xun QJ, Feng F, Chen YZ, Su Y, Shen YY, Chen Y, Geng MY, Ding K, Li YL, Xie H, Ding J. Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R. Acta Pharmacol Sin. 2018 Nov;39(11):1768-1776. doi: 10.1038/s41401-018-0056-0. Epub 2018 Jul 3. PubMed PMID: 29968849; PubMed Central PMCID: PMC6289367.