D2923

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564640

CAS#: NONE

Description: D2923 is a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R).


Price and Availability

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D2923 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564640
Name: D2923
CAS#: NONE
Chemical Formula: C31H36Cl2N8O2
Exact Mass: 622.2338
Molecular Weight: 623.58
Elemental Analysis: C, 59.71; H, 5.82; Cl, 11.37; N, 17.97; O, 5.13


Synonym: D-2923; D 2923; D2923

IUPAC/Chemical Name: (S)-3-(2,6-Dichlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(1-propionylpyrrolidin-3-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

InChi Key: UAEJGNXQHGHNAP-QHCPKHFHSA-N

InChi Code: InChI=1S/C31H36Cl2N8O2/c1-4-27(42)39-11-10-23(19-39)41-29-21(18-40(31(41)43)28-24(32)6-5-7-25(28)33)17-34-30(36-29)35-22-8-9-26(20(2)16-22)38-14-12-37(3)13-15-38/h5-9,16-17,23H,4,10-15,18-19H2,1-3H3,(H,34,35,36)/t23-/m0/s1

SMILES Code: O=C1N([C@@H]2CN(C(CC)=O)CC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)=NC=C3CN1C6=C(Cl)C=CC=C6Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Liu YQ, Wang YN, Lu XY, Tong LJ, Li Y, Zhang T, Xun QJ, Feng F, Chen YZ, Su Y, Shen YY, Chen Y, Geng MY, Ding K, Li YL, Xie H, Ding J. Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R. Acta Pharmacol Sin. 2018 Nov;39(11):1768-1776. doi: 10.1038/s41401-018-0056-0. Epub 2018 Jul 3. PubMed PMID: 29968849; PubMed Central PMCID: PMC6289367.