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VAS 2870
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584724

CAS#: 722456-31-7

Description: VAS 2870 is a NADPH oxidase (Nox) inhibitor that enhances TGF-β-induced apoptosis of liver tumor cells.


Price and Availability

Size
Price
5mg
USD 250
Size
Price
25mg
USD 550
Size
Price

VAS 2870, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584724
Name: VAS 2870
CAS#: 722456-31-7
Chemical Formula: C18H12N6OS
Exact Mass: 360.0793
Molecular Weight: 360.395
Elemental Analysis: C, 59.99; H, 3.36; N, 23.32; O, 4.44; S, 8.90


Synonym: VAS 2870

IUPAC/Chemical Name: 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine

InChi Key: HZSOKHVVANONPV-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2

SMILES Code: C12=NC=NC(SC3=NC4=CC=CC=C4O3)=C1N=NN2CC5=CC=CC=C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

Stielow et al (2006) Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem.Biophys.Res.Commun. 344 200 PMID: 16603125

Sancho and Fabregat et al (2011) The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem.Pharmacol. 81 917 PMID: 21276422

ten Freyhaus et al (2006) Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc.Res. 71 331 PMID: 16545786