WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564624
CAS#: 1609659-32-6
Description: IBE-667 is an ICAM-1 binding enhancer for LFA-1. Cellular assays demonstrate the activity of IBE-667 in promoting the binding of LFA-1 on activated immune cells to ICAM-1. IBE-667 increases the binding of biotinylated soluble ICAM-1 to activated T-cells as determined by staining with PE-streptavidin and FACS analysis. IBE-667 leads to a concentration dependent induction of T-cell aggregation after activation by anti CD3 and anti CD28 antibodies. IBE-667 induced T-cell aggregation can be completely reversed with an LFA-1 neutralizing antibody.
MedKoo Cat#: 564624
Name: IBE-667
CAS#: 1609659-32-6
Chemical Formula: C25H25N5O2
Exact Mass: 427.2008
Molecular Weight: 427.51
Elemental Analysis: C, 70.24; H, 5.89; N, 16.38; O, 7.48
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Synonym: IBE667; IBE 667; IBE-667
IUPAC/Chemical Name: N-(3-Aminopropyl)-4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzamide
InChi Key: CGHZINICBUGRGZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H25N5O2/c1-27-24(31)18-11-13-20(14-12-18)30-22-6-3-2-5-21(22)23(29-30)17-7-9-19(10-8-17)25(32)28-16-4-15-26/h2-3,5-14H,4,15-16,26H2,1H3,(H,27,31)(H,28,32)
SMILES Code: O=C(NCCCN)C1=CC=C(C2=NN(C3=CC=C(C(NC)=O)C=C3)C4=C2C=CC=C4)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 427.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Abdullahi M, Olotu FA, Soliman ME. Dynamics of allosteric modulation of lymphocyte function associated antigen-1 closure-open switch: unveiling the structural mechanisms associated with outside-in signaling activation. Biotechnol Lett. 2017 Dec;39(12):1843-1851. doi: 10.1007/s10529-017-2432-0. Epub 2017 Sep 16. PubMed PMID: 28918491.
2: Hintersteiner M, Kallen J, Schmied M, Graf C, Jung T, Mudd G, Shave S, Gstach H, Auer M. Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding. Angew Chem Int Ed Engl. 2014 Apr 22;53(17):4322-6. doi: 10.1002/anie.201310240. Epub 2014 Apr 1. PubMed PMID: 24692345; PubMed Central PMCID: PMC4314669.
