IBE-667

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564624

CAS#: 1609659-32-6

Description: IBE-667 is an ICAM-1 binding enhancer for LFA-1. Cellular assays demonstrate the activity of IBE-667 in promoting the binding of LFA-1 on activated immune cells to ICAM-1. IBE-667 increases the binding of biotinylated soluble ICAM-1 to activated T-cells as determined by staining with PE-streptavidin and FACS analysis. IBE-667 leads to a concentration dependent induction of T-cell aggregation after activation by anti CD3 and anti CD28 antibodies. IBE-667 induced T-cell aggregation can be completely reversed with an LFA-1 neutralizing antibody.


Chemical Structure

img
IBE-667
CAS# 1609659-32-6

Theoretical Analysis

MedKoo Cat#: 564624
Name: IBE-667
CAS#: 1609659-32-6
Chemical Formula: C25H25N5O2
Exact Mass: 427.2008
Molecular Weight: 427.51
Elemental Analysis: C, 70.24; H, 5.89; N, 16.38; O, 7.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: IBE667; IBE 667; IBE-667

IUPAC/Chemical Name: N-(3-Aminopropyl)-4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzamide

InChi Key: CGHZINICBUGRGZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H25N5O2/c1-27-24(31)18-11-13-20(14-12-18)30-22-6-3-2-5-21(22)23(29-30)17-7-9-19(10-8-17)25(32)28-16-4-15-26/h2-3,5-14H,4,15-16,26H2,1H3,(H,27,31)(H,28,32)

SMILES Code: O=C(NCCCN)C1=CC=C(C2=NN(C3=CC=C(C(NC)=O)C=C3)C4=C2C=CC=C4)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 427.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Abdullahi M, Olotu FA, Soliman ME. Dynamics of allosteric modulation of lymphocyte function associated antigen-1 closure-open switch: unveiling the structural mechanisms associated with outside-in signaling activation. Biotechnol Lett. 2017 Dec;39(12):1843-1851. doi: 10.1007/s10529-017-2432-0. Epub 2017 Sep 16. PubMed PMID: 28918491.

2: Hintersteiner M, Kallen J, Schmied M, Graf C, Jung T, Mudd G, Shave S, Gstach H, Auer M. Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding. Angew Chem Int Ed Engl. 2014 Apr 22;53(17):4322-6. doi: 10.1002/anie.201310240. Epub 2014 Apr 1. PubMed PMID: 24692345; PubMed Central PMCID: PMC4314669.