WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564623
Description: JFD00950 is a human flap endonuclease 1 (FEN1) inhibitor with in vitro inhibition of flap cleavage activity as well as cytotoxic activity against a colon cancer cell line, DLD-1.
MedKoo Cat#: 564623
Chemical Formula: C16H6Cl4O3
Exact Mass: 385.9071
Molecular Weight: 388.02
Elemental Analysis: C, 49.53; H, 1.56; Cl, 36.54; O, 12.37
This product is not in stock, which may be available by custom synthesis.
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Synonym: JFD-00950; JFD 00950; JFD00950
IUPAC/Chemical Name: 2-Chloro-3-(2,4,5-trichlorophenoxy)-1,4-dihydronaphthalene-1,4-dione
InChi Key: ZFBYNRLQXMCZPT-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H6Cl4O3/c17-9-5-11(19)12(6-10(9)18)23-16-13(20)14(21)7-3-1-2-4-8(7)15(16)22/h1-6H
SMILES Code: O=C1C(Cl)=C(OC2=CC(Cl)=C(Cl)C=C2Cl)C(C3=C1C=CC=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 388.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Deshmukh AL, Chandra S, Singh DK, Siddiqi MI, Banerjee D. Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening. Mol Biosyst. 2017 Jul 25;13(8):1630-1639. doi: 10.1039/c7mb00118e. PubMed PMID: 28685785.