Quazodine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584718

CAS#: 4015-32-1

Description: Quazodine is a phosphodiesterase inhibitor.


Chemical Structure

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Quazodine
CAS# 4015-32-1

Theoretical Analysis

MedKoo Cat#: 584718
Name: Quazodine
CAS#: 4015-32-1
Chemical Formula: C12H14N2O2
Exact Mass: 218.11
Molecular Weight: 218.256
Elemental Analysis: C, 66.04; H, 6.47; N, 12.84; O, 14.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Quazodine; MJ 1988

IUPAC/Chemical Name: 6,7-Dimethoxy-4-ethylquinazoline

InChi Key: STAYVYIMUXVGBN-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14N2O2/c1-4-9-8-5-11(15-2)12(16-3)6-10(8)14-7-13-9/h5-7H,4H2,1-3H3

SMILES Code: CCC1=C2C=C(OC)C(OC)=CC2=NC=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 218.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Parratt JR, Winslow E. Actions of quazodine (MJ1988) on smooth muscle. Br J Pharmacol. 1971 Nov;43(3):612-23. PubMed PMID: 4333696; PubMed Central PMCID: PMC1665786.

2: Parratt JR, Winslow E. Cardiovascular pharmacology of quazodine (MJ-1988), with particular reference to effects of myocardial blood flow and metabolic heat production. Br J Pharmacol. 1971 Jun;42(2):193-204. PubMed PMID: 4397441; PubMed Central PMCID: PMC1667164.

3: Parratt JR, Winslow E. Haemodynamic and coronary effects of quazodine in cats with developing myocardial infarcts. J Pharm Pharmacol. 1972 Sep;24(9):673-80. PubMed PMID: 4404069.

4: Kane KA, Morcillo-Sanchez EJ, Parratt JR, Rodger IW, Shahid M. The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat. Br J Pharmacol. 1985 Jan;84(1):139-45. PubMed PMID: 2579698; PubMed Central PMCID: PMC1987211.

5: Amer MS, Browder HP. Effect of quazodine on phosphodiesterase. Proc Soc Exp Biol Med. 1971 Mar;136(3):750-2. PubMed PMID: 4324513.

6: Gomoll AW, Byrne JE, McKinney GR. Interactions of quazodine with cardiotoxic doses of ouabain in the anesthetized dog. Arch Int Pharmacodyn Ther. 1974 Jan;207(1):16-27. PubMed PMID: 4151046.

7: Bowman WC, Khan HH, Savage AO. Some antagonists of dantrolene sodium on the isolated diaphragm muscle of the rat. J Pharm Pharmacol. 1977 Oct;29(10):616-25. PubMed PMID: 21242.

8: Bartek MJ, LaBudde JA. Metabolism of (14C)-quazodine in the rat, dog, and man. Toxicol Appl Pharmacol. 1976 May;36(2):307-22. PubMed PMID: 1273849.

9: Nott MW, Winslow E. Effects of quazodine (MJ 1988) on contractions of the isolated hemidiaphragm of the rat and the biventer cervicis muscle of the chick. Br J Pharmacol. 1973 Jul;48(3):409-17. PubMed PMID: 4764289; PubMed Central PMCID: PMC1776117.

10: Nott MW, Winslow E. Proceedings: Effects of quazodine on cat fast- and slow-contracting skeletal muscles. Br J Pharmacol. 1974 Mar;50(3):470P-471P. PubMed PMID: 4853813; PubMed Central PMCID: PMC1776710.

11: Parratt JR, Winslow E. The effects of quazodine on myocardial blood flow in developing myocardial infarcts. J Pharm Pharmacol. 1971 Dec;23:224S-225S. PubMed PMID: 4401475.

12: Parratt JR, Winslow E. The haemodynamic effects of quazodine, a cardiac stimulant, in experimental E. coli endotoxin shock in the cat. Clin Exp Pharmacol Physiol. 1974 Jan-Feb;1(1):31-41. PubMed PMID: 4616780.

13: Friedman Y, Lang M, Burke G. Further characterization of bovine thyroid prostaglandin synthase. Biochim Biophys Acta. 1975 Aug 26;397(2):331-41. PubMed PMID: 168923.

14: Greenslade FC, Scott CK, Newquist KL, Krider KM, Chasin M. Heterogeneity of biochemical actions among vasodilators. J Pharm Sci. 1982 Jan;71(1):94-100. PubMed PMID: 6276530.

15: Burke G, Chang LL, Szabo M. Thyrotropin and cyclic nucleotide effects on prostaglandin levels in isolated thyroid cells. Science. 1973 May 25;180(4088):872-5. PubMed PMID: 4350404.