WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564583
CAS#: 2112809-98-8
Description: JC-171 is an NLRP3 inflammasome inhibitor with biological activity in vivo, for potential treatment of multiple sclerosis. JC-171 treatment was shown to delay the progression and reduce the severity of experimental autoimmune encephalomyelitis (EAE), and a mouse model of MS, in both prophylactic and therapeutic settings.
MedKoo Cat#: 564583
Name: JC-171
CAS#: 2112809-98-8
Chemical Formula: C16H17ClN2O5S
Exact Mass: 384.0547
Molecular Weight: 384.83
Elemental Analysis: C, 49.94; H, 4.45; Cl, 9.21; N, 7.28; O, 20.79; S, 8.33
This product is not in stock, which may be available by custom synthesis.
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Synonym: JC171; JC 171; JC-171
IUPAC/Chemical Name: 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide
InChi Key: KQRQPMUPYDOTCA-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H17ClN2O5S/c1-24-15-7-4-12(17)10-14(15)16(20)18-9-8-11-2-5-13(6-3-11)25(22,23)19-21/h2-7,10,19,21H,8-9H2,1H3,(H,18,20)
SMILES Code: O=C(NCCC1=CC=C(S(=O)(NO)=O)C=C1)C2=CC(Cl)=CC=C2OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 384.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Guo C, Fulp JW, Jiang Y, Li X, Chojnacki JE, Wu J, Wang XY, Zhang S. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. ACS Chem Neurosci. 2017 Oct 18;8(10):2194-2201. doi: 10.1021/acschemneuro.7b00124. Epub 2017 Jul 13. PubMed PMID: 28653829; PubMed Central PMCID: PMC5672903.
