JNJ0966
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564581

CAS#: 315705-75-0

Description: JNJ0966 is a highly selective allosteric inhibitor of matrix metalloproteinase-9 (MMP-9).


Chemical Structure

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JNJ0966
CAS# 315705-75-0

Theoretical Analysis

MedKoo Cat#: 564581
Name: JNJ0966
CAS#: 315705-75-0
Chemical Formula: C16H16N4O2S2
Exact Mass: 360.0715
Molecular Weight: 360.45
Elemental Analysis: C, 53.32; H, 4.47; N, 15.54; O, 8.88; S, 17.79

Price and Availability

Size Price Availability Quantity
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 650.0 2 Weeks
500.0mg USD 1450.0 2 Weeks
1.0g USD 2250.0 2 Weeks
2.0g USD 3850.0 2 Weeks
5.0g USD 5850.0 2 Weeks
10.0g USD 8450.0 2 Weeks
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Synonym: JNJ-0966; JNJ 0966; JNJ0966

IUPAC/Chemical Name: N-(2-((2-Methoxyphenyl)amino)-4'-methyl-[4,5'-bithiazol]-2'-yl)acetamide

InChi Key: ZADCDCMLLGDCRM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21)

SMILES Code: CC(NC1=NC(C)=C(C2=CSC(NC3=CC=CC=C3OC)=N2)S1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 360.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Scannevin RH, Alexander R, Haarlander TM, Burke SL, Singer M, Huo C, Zhang YM, Maguire D, Spurlino J, Deckman I, Carroll KI, Lewandowski F, Devine E, Dzordzorme K, Tounge B, Milligan C, Bayoumy S, Williams R, Schalk-Hihi C, Leonard K, Jackson P, Todd M, Kuo LC, Rhodes KJ. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292(43):17963-17974. doi: 10.1074/jbc.M117.806075. Epub 2017 Aug 31. PubMed PMID: 28860188; PubMed Central PMCID: PMC5663893.

JNJ0966

50.0mg / USD 250.0