A1874
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573175

CAS#: 2064292-12-0

Description: A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells.


Price and Availability

Size
Price

50mg
USD 850
500mg
USD 2950
Size
Price

100mg
USD 1450
1g
USD 4250
Size
Price

200mg
USD 1950
2g
USD 7850

A1874, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 573175
Name: A1874
CAS#: 2064292-12-0
Chemical Formula: C58H62Cl3F2N9O7S
Exact Mass: 1171.3527
Molecular Weight: 1173.6
Elemental Analysis: C, 59.36; H, 5.33; Cl, 9.06; F, 3.24; N, 10.74; O, 9.54; S, 2.73


Synonym: A1874, A-1874

IUPAC/Chemical Name: (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide

InChi Key: IPNTVOAQOGRLQB-JJMBTQCASA-N

InChi Code: InChI=1S/C58H62Cl3F2N9O7S/c1-32-33(2)80-56-48(32)51(35-11-14-37(59)15-12-35)67-44(53-71-70-34(3)72(53)56)29-47(73)65-19-21-77-23-25-79-26-24-78-22-20-66-54(74)36-13-18-43(45(27-36)76-7)68-55(75)52-49(39-9-8-10-41(61)50(39)63)58(31-64,46(69-52)30-57(4,5)6)40-17-16-38(60)28-42(40)62/h8-18,27-28,44,46,49,52,69H,19-26,29-30H2,1-7H3,(H,65,73)(H,66,74)(H,68,75)/t44-,46-,49-,52+,58-/m0/s1

SMILES Code: O=C([C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C3=CC=CC(Cl)=C3F)NC4=CC=C(C(NCCOCCOCCOCCNC(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)=O)C=C4OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Hines J, Lartigue S, Dong H, Qian Y, Crews CM. MDM2-recruiting PROTAC Offers Superior, Synergistic Anti-proliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53. Cancer Res. 2018 Nov 1. pii: canres.2918.2018. doi: 10.1158/0008-5472.CAN-18-2918. [Epub ahead of print] PubMed PMID: 30385614.