We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564561

CAS#: 148451-96-1

Description: L-732138 is an NK1 receptor antagonist.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 265 2 Weeks
50mg USD 865 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

L-732138, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data, and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 564561
Name: L-732138
CAS#: 148451-96-1
Chemical Formula: C22H18F6N2O3
Exact Mass: 472.1222
Molecular Weight: 472.39
Elemental Analysis: C, 55.94; H, 3.84; F, 24.13; N, 5.93; O, 10.16

Synonym: 3,5-bis(TFM)Bz NAcTrp; L732138; L 732138; L-732138; L-732, 138

IUPAC/Chemical Name: [3,5-Bis(trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-indol-3-yl)propanoate


InChi Code: InChI=1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1

SMILES Code: O=C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@@H](NC(C)=O)CC2=CNC3=C2C=CC=C3

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Molinos-Quintana A, Trujillo-Hacha P, Piruat JI, Bejarano-García JA, García-Guerrero E, Pérez-Simón JA, Muñoz M. Human acute myeloid leukemia cells express Neurokinin-1 receptor, which is involved in the antileukemic effect of Neurokinin-1 receptor antagonists. Invest New Drugs. 2018 May 2. doi: 10.1007/s10637-018-0607-8. [Epub ahead of print] PubMed PMID: 29721755.

2: Muñoz M, Rosso M, Coveñas R. The NK-1 receptor antagonist L-732,138 induces apoptosis in human gastrointestinal cancer cell lines. Pharmacol Rep. 2017 Aug;69(4):696-701. doi: 10.1016/j.pharep.2017.02.002. Epub 2017 Feb 12. PubMed PMID: 28550801.

3: Onaga T, Oh-ishi T, Shimoda T, Nishimoto S, Hayashi H. Role of tachykinin and neurokinin receptors in the regulation of ovine omasal contractions. Regul Pept. 2012 Jan 10;173(1-3):64-73. doi: 10.1016/j.regpep.2011.09.007. Epub 2011 Oct 3. PubMed PMID: 21971117.