Varespladib Sodium
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530254

CAS#: 172733-42-5 (sodium)

Description: Varespladib, aslo known as LY315920, is a secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Varespladib reduces atherosclerosis and aneurysm formation in ApoE-/- mice and in guinea pigs. Varespladib significantly reduces the post-ACS inflammatory response in those with and without diabetes. Varespladib may be potentially useful for treatment of coronary artery disease.

Chemical Structure

img
Varespladib Sodium
CAS# 172733-42-5 (sodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 530254
Name: Varespladib Sodium
CAS#: 172733-42-5 (sodium)
Chemical Formula: C21H19N2NaO5
Exact Mass: 402.12
Molecular Weight: 402.382
Elemental Analysis: C, 62.68; H, 4.76; N, 6.96; Na, 5.71; O, 19.88

Price and Availability

Size Price Availability Quantity
10mg USD 400 2 Weeks
25mg USD 850 2 Weeks
Bulk inquiry

Related CAS #: 172733-42-5 (sodium)   172732-68-2 (free acid)  

Synonym: Varespladib Sodium; Varespladib; LY315920; LY-315920; LY 315920; A-002; A002; A 002;

IUPAC/Chemical Name: Acetic acid, ((3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)-, monosodium salt

InChi Key: XZZUHXILQXLTGV-UHFFFAOYSA-M

InChi Code: InChI=1S/C21H20N2O5.Na/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13;/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25);/q;+1/p-1

SMILES Code: O=C([O-])COC1=CC=CC2=C1C(C(C(N)=O)=O)=C(CC)N2CC3=CC=CC=C3.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 402.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):463-93. PubMed PMID: 19907722.

2: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Jun;30(5):383-408. PubMed PMID: 18806898.

3: Tomita Y, Kuwabara K, Furue S, Tanaka K, Yamada K, Ueno M, Ono T, Maruyama T, Ajiki T, Onoyama H, Yamamoto M, Hori Y. Effect of a selective inhibitor of secretory phospholipase A2, S-5920/LY315920Na, on experimental acute pancreatitis in rats. J Pharmacol Sci. 2004 Oct;96(2):144-54. Epub 2004 Oct 2. PubMed PMID: 15467263.

4: Koike K, Yamamoto Y, Hori Y, Ono T. Group IIA phospholipase A2 mediates lung injury in intestinal ischemia-reperfusion. Ann Surg. 2000 Jul;232(1):90-7. PubMed PMID: 10862200; PubMed Central PMCID: PMC1421112.