Benzacin hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581623

CAS#: 71-79-4

Description: Benzacin hydrochloride is a biochemical.


Price and Availability

Size
Price

Size
Price

Size
Price

Benzacin hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 581623
Name: Benzacin hydrochloride
CAS#: 71-79-4
Chemical Formula: C18H22ClNO3
Exact Mass: 335.1288
Molecular Weight: 335.828
Elemental Analysis: C, 64.38; H, 6.60; Cl, 10.56; N, 4.17; O, 14.29


Synonym: Benzacin hydrochloride; Benzacin; Benzacin HCl; Benzacine; Benzacine hydrochloride; Difemin; Diphemin; 2-(Dimethylamino)ethyl benzilate hydrochloride.

IUPAC/Chemical Name: 2-(Dimethylamino)ethyl benzilate hydrochloride

InChi Key: IJKAOMCJQZGZPQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21NO3.ClH/c1-19(2)13-14-22-17(20)18(21,15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,21H,13-14H2,1-2H3;1H

SMILES Code: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C(OCCN(C)C)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Lu B, Breza JM, Contreras RJ. Temperature Influences Chorda Tympani Nerve Responses to Sweet, Salty, Sour, Umami, and Bitter Stimuli in Mice. Chem Senses. 2016 Aug 6. pii: bjw082. [Epub ahead of print] PubMed PMID: 27497433; PubMed Central PMCID: PMC5070488.

2: Kurowski P, Gawlak M, Szulczyk P. Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats. Neuroscience. 2015 Sep 10;303:474-88. doi: 10.1016/j.neuroscience.2015.07.023. Epub 2015 Jul 14. PubMed PMID: 26186898.

3: Breza JM, Contreras RJ. Acetic acid modulates spike rate and spike latency to salt in peripheral gustatory neurons of rats. J Neurophysiol. 2012 Nov;108(9):2405-18. doi: 10.1152/jn.00114.2012. Epub 2012 Aug 15. PubMed PMID: 22896718; PubMed Central PMCID: PMC3545182.

4: Breza JM, Contreras RJ. Anion size modulates salt taste in rats. J Neurophysiol. 2012 Mar;107(6):1632-48. doi: 10.1152/jn.00621.2011. Epub 2011 Dec 28. PubMed PMID: 22205652; PubMed Central PMCID: PMC3311674.

5: Gabor A, Leenen FH. Mechanisms mediating sodium-induced pressor responses in the PVN of Dahl rats. Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1338-49. doi: 10.1152/ajpregu.00246.2011. Epub 2011 Jul 27. PubMed PMID: 21795639.

6: Steier R, Aradi M, Pál J, Bukovics P, Perlaki G, Orsi G, Janszky J, Schwarcz A, Sulyok E, Dóczi T. The influence of benzamil hydrochloride on the evolution of hyponatremic brain edema as assessed by in vivo MRI study in rats. Acta Neurochir (Wien). 2011 Oct;153(10):2091-7; discussion 2097. doi: 10.1007/s00701-011-0996-3. Epub 2011 Mar 29. PubMed PMID: 21445679.

7: Breza JM, Nikonov AA, Contreras RJ. Response latency to lingual taste stimulation distinguishes neuron types within the geniculate ganglion. J Neurophysiol. 2010 Apr;103(4):1771-84. doi: 10.1152/jn.00785.2009. Epub 2010 Jan 27. PubMed PMID: 20107132; PubMed Central PMCID: PMC2853290.

8: Sulyok E, Pál J, Vajda Z, Steier R, Dóczi T. Benzamil prevents brain water accumulation in hyponatraemic rats. Acta Neurochir (Wien). 2009 Sep;151(9):1121-5. doi: 10.1007/s00701-009-0354-x. Epub 2009 May 5. PubMed PMID: 19415169.

9: Abrams JM, Osborn JW. A role for benzamil-sensitive proteins of the central nervous system in the pathogenesis of salt-dependent hypertension. Clin Exp Pharmacol Physiol. 2008 May;35(5-6):687-94. doi: 10.1111/j.1440-1681.2008.04929.x. Review. PubMed PMID: 18387084; PubMed Central PMCID: PMC2693203.

10: Moudgil P, Gupta A, Sharma A, Gupta S, Tiwary AK. Potentiation of spermicidal activity of 2',4'-dichlorobenzamil by lidocaine. Indian J Exp Biol. 2002 Dec;40(12):1373-7. PubMed PMID: 12974399.

11: Peti-Peterdi J, Warnock DG, Bell PD. Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol. 2002 May;13(5):1131-5. PubMed PMID: 11960999.

12: Patni AK, Gupta S, Sharma A, Tiwary AK, Garg SK. Role of intracellular calcium in the spermicidal action of 2',4'-dichlorobenzamil, a novel contact spermicide. J Pharm Pharmacol. 2001 Oct;53(10):1387-92. PubMed PMID: 11697547.

13: Uchikado H, Tanaka E, Yamamoto S, Isagai T, Shigemori M, Higashi H. Na+/Ca2+ exchanger activity induces a slow DC potential after in vitro ischemia in rat hippocampal CA1 region. Neurosci Res. 2000 Feb;36(2):129-40. PubMed PMID: 10711810.

14: Nishimura M, Ohtsuka K, Takahashi H, Yoshimura M. Role of FMRFamide-activated brain sodium channel in salt-sensitive hypertension. Hypertension. 2000 Jan;35(1 Pt 2):443-50. PubMed PMID: 10642339.

15: Bielfeld-Ackermann A, Range C, Korbmacher C. Maitotoxin (MTX) activates a nonselective cation channel in Xenopus laevis oocytes. Pflugers Arch. 1998 Aug;436(3):329-37. PubMed PMID: 9644213.

16: Nishimura M, Ohtsuka K, Nanbu A, Takahashi H, Yoshimura M. Benzamil blockade of brain Na+ channels averts Na(+)-induced hypertension in rats. Am J Physiol. 1998 Mar;274(3 Pt 2):R635-44. PubMed PMID: 9530228.

17: Cox T. Amiloride analog stimulation of short-circuit current in larval frog skin epithelium. J Exp Biol. 1997 Dec;200(Pt 23):3055-65. PubMed PMID: 9359894.

18: Lundy RF Jr, Contreras RJ. Temperature and amiloride alter taste nerve responses to Na+, K+, and NH+4 salts in rats. Brain Res. 1997 Jan 9;744(2):309-17. PubMed PMID: 9027390.

19: Delmas P, Niel JP, Gola M. Muscarinic activation of a novel voltage-sensitive inward current in rabbit prevertebral sympathetic neurons. Eur J Neurosci. 1996 Mar;8(3):598-610. PubMed PMID: 8963452.