WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564526

CAS#: 112408-67-0

Description: 3-Deoxysappanchalcone is a natural anti-inflammatory agent, inducing heme oxygenase-1 via activation of the AKT/mTOR pathway in murine macrophages.

Chemical Structure

CAS# 112408-67-0

Theoretical Analysis

MedKoo Cat#: 564526
Name: 3-Deoxysappanchalcone
CAS#: 112408-67-0
Chemical Formula: C16H14O4
Exact Mass: 270.09
Molecular Weight: 270.280
Elemental Analysis: C, 71.10; H, 5.22; O, 23.68

Price and Availability

Size Price Availability Quantity
5mg USD 550 2 Weeks
10mg USD 950 2 Weeks
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Synonym: 2'-O-Methylisoliquiritigenin; 3-Deoxysappanchalcone

IUPAC/Chemical Name: (E)-1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one


InChi Code: InChI=1S/C16H14O4/c1-20-16-10-13(18)7-8-14(16)15(19)9-4-11-2-5-12(17)6-3-11/h2-10,17-18H,1H3/b9-4+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 270.280000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Escobar-Ramos A, Lobato-García CE, Zamilpa A, Gómez-Rivera A, Tortoriello J, González-Cortazar M. Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity. Molecules. 2017 Aug 24;22(9). pii: E1405. doi: 10.3390/molecules22091405. PubMed PMID: 28837100; PubMed Central PMCID: PMC6151460. 2: Seo H, Kim S, Mahmud HA, Islam MI, Nam KW, Lee BE, Lee H, Cho ML, Shin HM, Song HY. In vitro Antitubercular Activity of 3-Deoxysappanchalcone Isolated From the Heartwood of Caesalpinia sappan Linn. Phytother Res. 2017 Oct;31(10):1600-1606. doi: 10.1002/ptr.5890. Epub 2017 Aug 17. PubMed PMID: 28816372. 3: Kim YE, Choi HC, Lee IC, Yuk DY, Lee H, Choi BY. 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. Biomol Ther (Seoul). 2016 Nov 1;24(6):572-580. doi: 10.4062/biomolther.2016.183. PubMed PMID: 27795451; PubMed Central PMCID: PMC5098535. 4: Kim JH, Choo YY, Tae N, Min BS, Lee JH. The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages. Int Immunopharmacol. 2014 Oct;22(2):420-6. doi: 10.1016/j.intimp.2014.07.025. Epub 2014 Aug 1. PubMed PMID: 25091623. 5: Yang F, Zhou WL, Liu AL, Qin HL, Lee SM, Wang YT, Du GH. The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation. Planta Med. 2012 Jun;78(10):968-73. doi: 10.1055/s-0031-1298620. Epub 2012 May 30. PubMed PMID: 22648377. 6: Youn UJ, Nam KW, Kim HS, Choi G, Jeong WS, Lee MY, Chae S. 3-Deoxysappanchalcone inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in human keratinocytes through activated protein-1 inhibition and nuclear factor-kappa B DNA binding activity. Biol Pharm Bull. 2011;34(6):890-3. PubMed PMID: 21628889.