LY-228729

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530250

CAS#: 137641-36-2

Description: LY-228729 is a bioactive chemical.

Chemical Structure

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LY-228729
CAS# 137641-36-2
Instruction

Theoretical Analysis

MedKoo Cat#: 530250
Name: LY-228729
CAS#: 137641-36-2
Chemical Formula: C27H34N4O4
Exact Mass: 478.26
Molecular Weight: 478.593
Elemental Analysis: C, 67.76; H, 7.16; N, 11.71; O, 13.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LY-228729

IUPAC/Chemical Name: 4-(Dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indole-6-carboxamide hippurate,L-

InChi Key: WNHCMVMMLWRHHG-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H25N3O.C9H9NO3/c1-3-7-21(8-4-2)13-9-12-11-20-16-6-5-14(18(19)22)15(10-13)17(12)16;11-8(12)6-10-9(13)7-4-2-1-3-5-7/h5-6,11,13,20H,3-4,7-10H2,1-2H3,(H2,19,22);1-5H,6H2,(H,10,13)(H,11,12)

SMILES Code: O=C(C1=C2C3=C(NC=C3CC(N(CCC)CCC)C2)C=C1)N.O=C(C4=CC=CC=C4)NCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 478.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cannizzaro C, Plescia F, Gagliano M, Cannizzaro G, Mantia G, La Barbera M, Provenzano G, Cannizzaro E. Perinatal exposure to 5-methoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat. Behav Brain Res. 2008 Jan 10;186(1):98-106. Epub 2007 Aug 2. PubMed PMID: 17825441.

2: Winsauer PJ, Moerschbaecher JM. Differential effects of 5-HT agonists and antagonists on the repeated acquisition and performance of response sequences in monkeys. Behav Pharmacol. 2000 Nov;11(7-8):535-53. PubMed PMID: 11198126.

3: Cohen ML, Schenck KW, Hemrick-Luecke SH. 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):1195-201. PubMed PMID: 10454495.

4: Wolff MC, Leander JD. Effects of a 5-HT1A receptor agonist on acute and delayed cyclophosphamide-induced vomiting. Eur J Pharmacol. 1997 Dec 11;340(2-3):217-20. PubMed PMID: 9537818.

5: Cannizzaro C, Cannizzaro E, Gagliano M, Mineo A. Locomotor and antidepressant-like effects of 5-HT(1A) agonist LY 228729 in prenatally benzodiazepine-exposed rats. Eur Neuropsychopharmacol. 1998 Feb;8(1):27-32. PubMed PMID: 9452937.

6: Wolff MC, Leander JD. Comparison of the antiemetic effects of a 5-HT1A agonist, LY228729, and 5-HT3 antagonists in the pigeon. Pharmacol Biochem Behav. 1995 Nov;52(3):571-5. PubMed PMID: 8545476.

7: Foreman MM, Fuller RW, Leander JD, Benvenga MJ, Wong DT, Nelson DL, Calligaro DO, Swanson SP, Lucot JB, Flaugh ME. Preclinical studies on LY228729: a potent and selective serotonin1A agonist. J Pharmacol Exp Ther. 1993 Oct;267(1):58-71. PubMed PMID: 8229788.

8: Benvenga MJ, Leander JD. Antidepressant-like effect of LY228729 as measured in the rodent forced swim paradigm. Eur J Pharmacol. 1993 Aug 3;239(1-3):249-52. PubMed PMID: 8223903.

9: Swanson SP, Catlow J. Disposition of the novel serotonin agonist, LY228729, in monkeys and rats. Drug Metab Dispos. 1992 Jan-Feb;20(1):102-7. PubMed PMID: 1346983.

10: Slaughter JL, Harrington MA, Peroutka SJ. 6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents. Life Sci. 1990;47(15):1331-7. PubMed PMID: 2172684.