P217564

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564515

CAS#: NONE

Description: P217564 is a second-generation active site-targeted covalent irreversible inhibitor of USP7.


Price and Availability

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P217564 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564515
Name: P217564
CAS#: NONE
Chemical Formula: C16H12Cl2N2O5S2
Exact Mass: 445.9565
Molecular Weight: 447.3
Elemental Analysis: C, 42.96; H, 2.70; Cl, 15.85; N, 6.26; O, 17.88; S, 14.33


Synonym: P-217564; P 217564; P217564

IUPAC/Chemical Name: Methyl (E)-4-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophene-2-carboxamido)but-2-enoate

InChi Key: IXFIKHBITULBSK-ZZXKWVIFSA-N

InChi Code: InChI=1S/C16H12Cl2N2O5S2/c1-25-13(21)6-3-7-19-15(22)12-8-10(20(23)24)16(27-12)26-11-5-2-4-9(17)14(11)18/h2-6,8H,7H2,1H3,(H,19,22)/b6-3+

SMILES Code: O=C(OC)/C=C/CNC(C1=CC([N+]([O-])=O)=C(SC2=CC=CC(Cl)=C2Cl)S1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S. Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60. PLoS One. 2017 Dec 13;12(12):e0189744. doi: 10.1371/journal.pone.0189744. eCollection 2017. PubMed PMID: 29236775; PubMed Central PMCID: PMC5728538.