BXL0124

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564487

CAS#: 685141-23-5

Description: BXL0124 is a gemini vitamin D analog which targets CD44-STAT3 signaling and inhibits breast cancer invasion.


Price and Availability

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BXL0124 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564487
Name: BXL0124
CAS#: 685141-23-5
Chemical Formula: C32H38D6F6O4
Exact Mass: 612.352
Molecular Weight: 612.73
Elemental Analysis: C, 62.73; H, 8.22; F, 18.60; O, 10.44


Synonym: BXL-0124; BXL 0124; BXL0124

IUPAC/Chemical Name: (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-7a-methyl-1-((R)-1,1,1-trifluoro-2,10-dihydroxy-10-(methyl-d3)-2-(trifluoromethyl)undec-3-yn-6-yl-11,11,11-d3)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

InChi Key: VSOWXEHVBCDXAY-CVRMBSQLSA-N

InChi Code: InChI=1S/C32H44F6O4/c1-20-23(18-24(39)19-27(20)40)12-11-22-9-6-16-29(4)25(13-14-26(22)29)21(8-5-15-28(2,3)41)10-7-17-30(42,31(33,34)35)32(36,37)38/h11-12,21,24-27,39-42H,1,5-6,8-10,13-16,18-19H2,2-4H3/b22-11+,23-12-/t21-,24-,25-,26+,27+,29-/m1/s1/i2D3,3D3

SMILES Code: C=C1[C@@H](O)C[C@H](O)C/C1=C/C=C2[C@H](CC[C@@H]3[C@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O)CC#CC(C(F)(F)F)(O)C(F)(F)F)[C@]3(C)CCC/2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Belorusova AY, Suh N, Lee HJ, So JY, Maehr H, Rochel N. Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D. J Steroid Biochem Mol Biol. 2017 Oct;173:69-74. doi: 10.1016/j.jsbmb.2016.09.015. Epub 2016 Sep 17. PubMed PMID: 27650654; PubMed Central PMCID: PMC5357203.