UCB-FcRn-303

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564457

CAS#: NONE

Description: UCB-FcRn-303 is an allosteric modulator of neonatal Fc receptor (FcRn) which binds to the extracellular domain of FcRn. UCB-FcRn-303 binds to the extracellular domain of FcRn with low μM affinity. The conserved binding site is located at the interface of β2m and the α-chain, featuring a tunnel-like cavity with solvent access from two different sides.

Chemical Structure

img
UCB-FcRn-303
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 564457
Name: UCB-FcRn-303
CAS#: NONE
Chemical Formula: C18H13F2N5O2
Exact Mass: 369.10
Molecular Weight: 369.330
Elemental Analysis: C, 58.54; H, 3.55; F, 10.29; N, 18.96; O, 8.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UCBFcRn303; UCB FcRn 303; UCB-FcRn-303

IUPAC/Chemical Name: Methyl 7-(3,5-difluorophenyl)-5-(pyridin-3-yl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate

InChi Key: XMWGQXBZBFXLGX-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H13F2N5O2/c1-27-17(26)14-15(10-3-2-4-21-8-10)24-18-22-9-23-25(18)16(14)11-5-12(19)7-13(20)6-11/h2-9,16H,1H3,(H,22,23,24)

SMILES Code: O=C(C1=C(C2=CC=CN=C2)NC3=NC=NN3C1C4=CC(F)=CC(F)=C4)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 369.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Stöppler D, Macpherson A, Smith-Penzel S, Basse N, Lecomte F, Deboves H, Taylor RD, Norman T, Porter J, Waters LC, Westwood M, Cossins B, Cain K, White J, Griffin R, Prosser C, Kelm S, Sullivan AH, Fox D 3rd, Carr MD, Henry A, Taylor R, Meier BH, Oschkinat H, Lawson AD. Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR. PLoS Biol. 2018 May 21;16(5):e2006192. doi: 10.1371/journal.pbio.2006192. PMID: 29782488; PMCID: PMC5983862.