JCP251
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564455

CAS#: 62252-26-0

Description: JCP251 is an inhibitor of serine hydrolases which also acts as a gamma-secretase inhibitor.


Chemical Structure

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JCP251
CAS# 62252-26-0

Theoretical Analysis

MedKoo Cat#: 564455
Name: JCP251
CAS#: 62252-26-0
Chemical Formula: C10H8ClNO3
Exact Mass: 225.0193
Molecular Weight: 225.63
Elemental Analysis: C, 53.23; H, 3.57; Cl, 15.71; N, 6.21; O, 21.27

Price and Availability

Size Price Availability Quantity
10.0mg USD 280.0 2 Weeks
50.0mg USD 750.0 2 Weeks
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Synonym: JLK6; JLK 6; JLK-6; JCP-251; JCP 251; JCP251

IUPAC/Chemical Name: 7-Amino-4-chloro-3-methoxy-isocoumarin

InChi Key: AMDGKLWVCUXONP-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H8ClNO3/c1-14-10-8(11)6-3-2-5(12)4-7(6)9(13)15-10/h2-4H,12H2,1H3

SMILES Code: O=C1OC(OC)=C(Cl)C2=C1C=C(N)C=C2

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 225.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Peuchmaur M, Lacour MA, Sévalle J, Lisowski V, Touati-Jallabe Y, Rodier F, Martinez J, Checler F, Hernandez JF. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21(4):1018-29. doi: 10.1016/j.bmc.2012.11.045. Epub 2012 Dec 5. PubMed PMID: 23294826.

2: Bihel F, Quéléver G, Lelouard H, Petit A, Alvès da Costa C, Pourquié O, Checler F, Thellend A, Pierre P, Kraus JL. Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease. Bioorg Med Chem. 2003 Jul 17;11(14):3141-52. PubMed PMID: 12818677.

JCP251

10.0mg / USD 280.0