Uprosertib HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564451

CAS#: 1047635-80-2 (HCl)

Description: Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Chemical Structure

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Uprosertib HCl
CAS# 1047635-80-2 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 564451
Name: Uprosertib HCl
CAS#: 1047635-80-2 (HCl)
Chemical Formula: C18H17Cl3F2N4O2
Exact Mass: 0.00
Molecular Weight: 465.710
Elemental Analysis: C, 46.42; H, 3.68; Cl, 22.84; F, 8.16; N, 12.03; O, 6.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1047635-80-2 (HCl)   1047634-65-0 (free base)  

Synonym: GSK2141795, GSK2141795, GSK 2141795, GSK795, GSK795, GSK 795, Uprosertib; Uprosertib HCl; Uprosertib hydrochloride;

IUPAC/Chemical Name: 5-Chloro-4-(4-chloro-2-methyl-2H-pyrazol-3-yl)-furan-2-carboxylic acid [1-aminomethyl-2-(3,4-difluoro-phenyl)-ethyl]-amide Hydrochloride

InChi Key: LAPFKCIDRPWAFU-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16Cl2F2N4O2.ClH/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9;/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27);1H

SMILES Code: O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)O1)NC(CN)CC3=CC=C(F)C(F)=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 465.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dumble M, Crouthamel MC, Zhang SY, Schaber M, Levy D, Robell K, Liu Q, Figueroa DJ, Minthorn EA, Seefeld MA, Rouse MB, Rabindran SK, Heerding DA, Kumar R. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880. doi: 10.1371/journal.pone.0100880. eCollection 2014. PubMed PMID: 24978597; PubMed Central PMCID: PMC4076210.