Majucin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584669

CAS#: 114687-97-7

Description: Majucin is a sesquiterpene derived from Illicium sp. that possess complex caged chemical architecture and remarkable neurotrophic activities with potential activity against neurodegenerative diseases.

Chemical Structure

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Majucin
CAS# 114687-97-7
Instruction

Theoretical Analysis

MedKoo Cat#: 584669
Name: Majucin
CAS#: 114687-97-7
Chemical Formula: C15H20O8
Exact Mass: 328.12
Molecular Weight: 328.317
Elemental Analysis: C, 54.88; H, 6.14; O, 38.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Majucin

IUPAC/Chemical Name: 4,7a-Methano-3H,7aH-cyclopenta(e)furo(3,4-c)oxocin-3,6(7H)-dione, octahydro-3a,7,10,10a-tetrahydroxy-8,10b-dimethyl-, (3aR-(3a-alpha,4-alpha,7-beta,7a-alpha,8-beta,10-alpha,10a-alpha,10b-alpha))-

InChi Key: VXDVFPLMCHUTNP-KXGILDKWSA-N

InChi Code: InChI=1S/C15H20O8/c1-6-3-7(16)15(21)12(2)5-22-11(19)14(12,20)8-4-13(6,15)9(17)10(18)23-8/h6-9,16-17,20-21H,3-5H2,1-2H3/t6-,7-,8-,9+,12-,13+,14-,15+/m1/s1

SMILES Code: O=C1OC[C@]([C@]2(O)[C@@]3([C@H](C)C[C@H]2O)[C@H]4O)(C)[C@@]1(O)[C@](C3)([H])OC4=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 328.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Condakes ML, Hung K, Harwood SJ, Maimone TJ. Total Syntheses of (-)-Majucin and (-)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes. J Am Chem Soc. 2017 Dec 13;139(49):17783-17786. doi: 10.1021/jacs.7b11493. Epub 2017 Nov 26. PubMed PMID: 29148748; PubMed Central PMCID: PMC5729088.

2: Trzoss L, Xu J, Lacoske MH, Theodorakis EA. Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation. Beilstein J Org Chem. 2013 Jun 12;9:1135-40. doi: 10.3762/bjoc.9.126. Print 2013. PubMed PMID: 23843905; PubMed Central PMCID: PMC3701413.

3: Yokoyama R, Huang JM, Yang CS, Fukuyama Y. New seco-prezizaane-type sesquiterpenes, jiadifenin with neurotrophic activity and 1,2-dehydroneomajucin from Illicium jiadifengpi. J Nat Prod. 2002 Apr;65(4):527-31. PubMed PMID: 11975494.

4: Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10;19(20):6398-408. doi: 10.1002/chem.201300198. Epub 2013 Mar 22. PubMed PMID: 23526661; PubMed Central PMCID: PMC3875175.

5: Ma HJ, Ma CH, Huang JM. [Two new sesquiterpene lactones from the pericarp of Illicium macranthum]. Yao Xue Xue Bao. 2010 Mar;45(3):330-3. Chinese. PubMed PMID: 21351509.