WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564448
CAS#: 306733-22-2 (free base)
Description: F81-1144b is a matrix metalloproteinase inhibitor which reduces secretion of very low density lipoprotein-triacylglycerol, thereby lowering TAG levels in serum and the liver. F81-1144b also lowers VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose.
MedKoo Cat#: 564448
Name: F81-1144b
CAS#: 306733-22-2 (free base)
Chemical Formula: C27H37N3O5
Exact Mass: 483.2733
Molecular Weight: 483.61
Elemental Analysis: C, 67.06; H, 7.71; N, 8.69; O, 16.54
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 306733-22-2 (free base) 328081-16-9 (HCl)
Synonym: F811144b; F81 1144b; F81-1144b
IUPAC/Chemical Name: (S)-3-(4-(Aminomethyl)phenyl)-2-((2R,3S)-3-(hydroxycarbamoyl)-2-isobutyl-6-phenylhexanamido)propanoic acid
InChi Key: GFAZZKCPOBPJMA-VXNXHJTFSA-N
InChi Code: InChI=1S/C27H37N3O5/c1-18(2)15-23(22(26(32)30-35)10-6-9-19-7-4-3-5-8-19)25(31)29-24(27(33)34)16-20-11-13-21(17-28)14-12-20/h3-5,7-8,11-14,18,22-24,35H,6,9-10,15-17,28H2,1-2H3,(H,29,31)(H,30,32)(H,33,34)/t22-,23+,24-/m0/s1
SMILES Code: O=C(O)[C@@H](NC([C@H](CC(C)C)[C@@H](C(NO)=O)CCCC1=CC=CC=C1)=O)CC2=CC=C(CN)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 483.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kawashima Y, Eguchi Y, Yamazaki T, Karahashi M, Kawai H, Kudo N. Reduction in Secretion of Very Low Density Lipoprotein-Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia. J Pharmacol Exp Ther. 2018 Jul;366(1):194-204. doi: 10.1124/jpet.117.246165. Epub 2018 May 7. PubMed PMID: 29735610.
