ZK824859 HCl
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MedKoo CAT#: 555363

CAS#: 2436760-76-6 (HCl)

Description: ZK824859 is a selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.


Chemical Structure

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ZK824859 HCl
CAS# 2436760-76-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 555363
Name: ZK824859 HCl
CAS#: 2436760-76-6 (HCl)
Chemical Formula: C23H24Cl2F2N2O4
Exact Mass: 428.15
Molecular Weight: 501.352
Elemental Analysis: C, 55.10; H, 4.83; Cl, 14.14; F, 7.58; N, 5.59; O, 12.76

Price and Availability

Size Price Availability Quantity
5mg USD 625 2 Weeks
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Related CAS #: 2254001-81-3 (free acid)   2436760-76-6 (HCl)  

Synonym: ZK824859; ZK-824859; ZK 824859; ZK824859 HCl; ZK824859 hydrochloride

IUPAC/Chemical Name: (R)-2-((6-((3'-(Aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid dihydrochloride

InChi Key: AQXUHWUZKYSBNO-FAVHNTAZSA-N

InChi Code: InChI=1S/C23H22F2N2O4.2ClH/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26;;/h4-11,20H,3,12,26H2,1-2H3,(H,28,29);2*1H/t20-;;/m1../s1

SMILES Code: CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 501.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan
K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C,
Sukovich D, Whitlow M, Chen D, Buckman BO. Discovery of selective urokinase
plasminogen activator (uPA) inhibitors as a potential treatment for multiple
sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi:
10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. PubMed PMID: 30201291.