WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407951

CAS#: 2443816-45-1

Description: ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM. ULK-101 suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. ULK-101 represents a powerful molecular tool to study the role of autophagy in cancer cells and to evaluate the therapeutic potential of autophagy inhibition.

Chemical Structure

CAS# 2443816-45-1

Theoretical Analysis

MedKoo Cat#: 407951
Name: ULK-101
CAS#: 2443816-45-1
Chemical Formula: C22H16F4N4OS
Exact Mass: 460.0981
Molecular Weight: 460.4506
Elemental Analysis: C, 57.39; H, 3.50; F, 16.50; N, 12.17; O, 3.47; S, 6.96

Price and Availability

Size Price Availability Quantity
1.0g USD 6950.0 2-3 months
2.0g USD 10950.0 2-3 months
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Synonym: ULK-101; ULK 101; ULK101;

IUPAC/Chemical Name: (S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide


InChi Code: InChI=1S/C22H16F4N4OS/c23-16-5-3-12(4-6-16)15-8-27-20-17(9-28-30(20)10-15)14-7-18(32-11-14)21(31)29-19(13-1-2-13)22(24,25)26/h3-11,13,19H,1-2H2,(H,29,31)/t19-/m0/s1

SMILES Code: O=C(C1=CC(C2=C3N=CC(C4=CC=C(F)C=C4)=CN3N=C2)=CS1)N[C@@H](C5CC5)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 460.4506 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Martin KR, Celano SL, Solitro AR, Gunaydin H, Scott M, O'Hagan RC, Shumway SD,
Fuller P, MacKeigan JP. A Potent and Selective ULK1 Inhibitor Suppresses
Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct
26;8:74-84. doi: 10.1016/j.isci.2018.09.012. Epub 2018 Sep 19. PubMed PMID:
30292171; PubMed Central PMCID: PMC6172447.


1.0g / USD 6950.0