WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407951
CAS#: 2443816-45-1
Description: ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM. ULK-101 suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. ULK-101 represents a powerful molecular tool to study the role of autophagy in cancer cells and to evaluate the therapeutic potential of autophagy inhibition.
MedKoo Cat#: 407951
Name: ULK-101
CAS#: 2443816-45-1
Chemical Formula: C22H16F4N4OS
Exact Mass: 460.0981
Molecular Weight: 460.4506
Elemental Analysis: C, 57.39; H, 3.50; F, 16.50; N, 12.17; O, 3.47; S, 6.96
Synonym: ULK-101; ULK 101; ULK101;
IUPAC/Chemical Name: (S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide
InChi Key: PFZRXJIYAFANHP-IBGZPJMESA-N
InChi Code: InChI=1S/C22H16F4N4OS/c23-16-5-3-12(4-6-16)15-8-27-20-17(9-28-30(20)10-15)14-7-18(32-11-14)21(31)29-19(13-1-2-13)22(24,25)26/h3-11,13,19H,1-2H2,(H,29,31)/t19-/m0/s1
SMILES Code: O=C(C1=CC(C2=C3N=CC(C4=CC=C(F)C=C4)=CN3N=C2)=CS1)N[C@@H](C5CC5)C(F)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 460.4506 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Martin KR, Celano SL, Solitro AR, Gunaydin H, Scott M, O'Hagan RC, Shumway SD,
Fuller P, MacKeigan JP. A Potent and Selective ULK1 Inhibitor Suppresses
Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct
26;8:74-84. doi: 10.1016/j.isci.2018.09.012. Epub 2018 Sep 19. PubMed PMID:
30292171; PubMed Central PMCID: PMC6172447.
