WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564442
Description: JJO-1 is a bi-quinoline that allosterically activates all AMPK αβγ isoforms in vitro except complexes containing the γ3 subunit. JJO-1 does not directly activate the autoinhibited α subunit kinase domain and differs among other known direct activators of AMPK in that allosteric activation occurs only at low ATP concentrations, and is not influenced by either mutation of the γ subunit adenylate-nucleotide binding sites or deletion of the β subunit carbohydrate-binding module.
MedKoo Cat#: 564442
Chemical Formula: C19H13N3
Exact Mass: 283.1109
Molecular Weight: 283.33
Elemental Analysis: C, 80.54; H, 4.62; N, 14.83
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: JJO1; JJO 1; JJO-1
IUPAC/Chemical Name: (E)-1-(Quinolin-2-yl)-N-(quinolin-3-yl)methanimine
InChi Key: FOOVLXYORBIGKA-UDWIEESQSA-N
InChi Code: InChI=1S/C19H13N3/c1-4-8-19-14(5-1)9-10-16(22-19)12-20-17-11-15-6-2-3-7-18(15)21-13-17/h1-13H/b20-12+
SMILES Code: C1(/N=C/C2=NC3=CC=CC=C3C=C2)=CC4=CC=CC=C4N=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 283.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Scott JW, Oakhill JS, Ling NX, Langendorf CG, Foitzik RC, Kemp BE, Issinger OG. ATP sensitive bi-quinoline activator of the AMP-activated protein kinase. Biochem Biophys Res Commun. 2014 Jan 10;443(2):435-40. doi: 10.1016/j.bbrc.2013.11.130. Epub 2013 Dec 8. PubMed PMID: 24332941.