WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564376
CAS#: NONE
Description: Haploscleridamine is an inhibitor of cathepsin K (CatK).
MedKoo Cat#: 564376
Name: Haploscleridamine
CAS#: NONE
Chemical Formula: C15H16N4
Exact Mass: 252.1375
Molecular Weight: 252.32
Elemental Analysis: C, 71.40; H, 6.39; N, 22.21
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Haploscleridamine
IUPAC/Chemical Name: 1-((1H-imidazol-5-yl)methyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
InChi Key: SLFMYESZZPZJHF-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H16N4/c1-2-4-13-11(3-1)12-5-6-17-14(15(12)19-13)7-10-8-16-9-18-10/h1-4,8-9,14,17,19H,5-7H2,(H,16,18)
SMILES Code: C1(CC2=CN=CN2)NCCC3=C1NC4=CC=CC=C43
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 252.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Patil AD, Freyer AJ, Carte B, Taylor PB, Johnson RK, Faulkner DJ. Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K. J Nat Prod. 2002 Apr;65(4):628-9. PubMed PMID: 11975521.
