WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564369
Description: G907 is a selective MsbA antagonist with bactericidal activity which reveals an unprecedented mechanism of ABC transporter inhibition.
MedKoo Cat#: 564369
Chemical Formula: C26H24ClNO3
Exact Mass: 433.1445
Molecular Weight: 433.93
Elemental Analysis: C, 71.97; H, 5.58; Cl, 8.17; N, 3.23; O, 11.06
This product is not in stock, which may be available by custom synthesis.
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Synonym: G-907; G 907; G907
IUPAC/Chemical Name: (E)-3-(6-(1-(2-Chloro-6-cyclopropylphenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid
InChi Key: HOMQCLNBKVHZGD-FMIVXFBMSA-N
InChi Code: InChI=1S/C26H24ClNO3/c1-15(25-20(16-5-6-16)3-2-4-22(25)27)31-19-10-11-23-21(13-19)26(17-7-8-17)18(14-28-23)9-12-24(29)30/h2-4,9-17H,5-8H2,1H3,(H,29,30)/b12-9+
SMILES Code: O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 433.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201. doi: 10.1038/s41586-018-0083-5. Epub 2018 May 2. PubMed PMID: 29720648.
2: Curtis MA, Aduse-Opoku J, Slaney JM, Rangarajan M, Booth V, Cridland J, Shepherd P. Characterization of an adherence and antigenic determinant of the ArgI protease of Porphyromonas gingivalis which is present on multiple gene products. Infect Immun. 1996 Jul;64(7):2532-9. PubMed PMID: 8698476; PubMed Central PMCID: PMC174107.