WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581552

CAS#: 13649-57-5

Description: 21-Desacetyl Deflazacort is a metabolite of Deflazacort (sc-204709), which is a systemic corticosteroid and a derivative of prednisolone. It is used for lupus and rheumatoid arthritis.

Chemical Structure

CAS# 13649-57-5

Theoretical Analysis

MedKoo Cat#: 581552
Name: 21-deacetyldeflazacort
CAS#: 13649-57-5
Chemical Formula: C23H29NO5
Exact Mass: 399.2046
Molecular Weight: 399.487
Elemental Analysis: C, 69.15; H, 7.32; N, 3.51; O, 20.02

Price and Availability

Size Price Availability Quantity
5.0mg USD 230.0 2 Weeks
10.0mg USD 380.0 2 Weeks
25.0mg USD 580.0 2 Weeks
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Synonym: 21-deacetyldeflazacort

IUPAC/Chemical Name: (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10-trimethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d]oxazol-4-one


InChi Code: InChI=1S/C23H29NO5/c1-12-24-23(18(28)11-25)19(29-12)9-16-15-5-4-13-8-14(26)6-7-21(13,2)20(15)17(27)10-22(16,23)3/h6-8,15-17,19-20,25,27H,4-5,9-11H2,1-3H3/t15-,16-,17-,19+,20+,21-,22-,23+/m0/s1

SMILES Code: CC1=N[C@@]2([C@@H](C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]23C)O1)C(=O)CO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 399.487 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ding W, Ding L, Li WB, Pan H, Lin HD. [Pharmacokinetics of deflazacort tablets in healthy Chinese volunteers]. Yao Xue Xue Bao. 2014 Jun;49(6):921-6. Chinese. PubMed PMID: 25212041.

2: Patel DP, Sharma P, Patel BM, Sanyal M, Singhal P, Shrivastav PS. Analysis of 21-hydroxy deflazacort in human plasma by UPLC-MS/MS: application to a bioequivalence study in healthy volunteers. J Pharm Biomed Anal. 2013 Nov;85:213-7. doi: 10.1016/j.jpba.2013.07.035. Epub 2013 Aug 6. PubMed PMID: 23973630.

3: Ifa DR, Moraes ME, Moraes MO, Santagada V, Caliendo G, de Nucci G. Determination of 21-hydroxydeflazacort in human plasma by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Application to bioequivalence study. J Mass Spectrom. 2000 Mar;35(3):440-5. PubMed PMID: 10767775.

4: Reynolds DL, Burmaster SD, Eichmeier LS. Quantitative determination of 21-hydroxy-deflazacort in human plasma using gradient semi-microbore liquid chromatography. Biomed Chromatogr. 1994 Sep-Oct;8(5):230-5. PubMed PMID: 7841767.

5: Santos-Montes A, Gonzalo-Lumbreras R, Gasco-Lopez AI, Izquierdo-Hornillos R. Extraction and high-performance liquid chromatographic separation of deflazacort and its metabolite 21-hydroxydeflazacort. Application to urine samples. J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):248-53. PubMed PMID: 7952078.

6: Omote M, Sakai K, Mizusawa H. Acute effects of deflazacort and its metabolite 21-desacetyl-deflazacort on allergic reactions. Arzneimittelforschung. 1994 Feb;44(2):149-53. PubMed PMID: 7511903.

7: Langhoff E, Olgaard K. In vitro immunosuppressive potency of deflazacort, a new bone-sparing corticosteroid on T lymphocytes, NK and K cells. Br J Clin Pharmacol. 1986 Feb;21(2):125-9. PubMed PMID: 3485440; PubMed Central PMCID: PMC1400905.

8: Russell JE, Gennari C, Imbimbo B, Avioli LV. Effects of deflazacort and the L-6485 metabolite on epiphyseal cartilage carbohydrate metabolism: comparison with prednisone. Horm Metab Res. 1985 Aug;17(8):402-5. PubMed PMID: 3840451.