WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581542
CAS#: 2623-22-5
Description: 15-Acetoxyscirpen-3,4-diol also known as 15-Acetoxyscirpenol, is a trichothecene mycotoxin and an apoptosis inducer.
MedKoo Cat#: 581542
Name: 15-Acetoxyscirpen-3,4-diol
CAS#: 2623-22-5
Chemical Formula: C17H24O6
Exact Mass: 324.1573
Molecular Weight: 324.37
Elemental Analysis: C, 62.95; H, 7.46; O, 29.59
Synonym: 15-Acetoxyscirpen-3,4-diol; 15-Acetylscirpenetriol; 15-Mono-O-acetylscirpenol; 15-Acetoxyscirpenol; 4-Deacetylanguidin; Deacetylanguidin
IUPAC/Chemical Name: (3-alpha)-12,13-Epoxytrichothec-9-ene-3,4,15-triol 15-acetate
InChi Key: IRXDUBNENLKYTC-QVVXDDFFSA-N
InChi Code: InChI=1S/C17H24O6/c1-9-4-5-16(7-21-10(2)18)11(6-9)23-14-12(19)13(20)15(16,3)17(14)8-22-17/h6,11-14,19-20H,4-5,7-8H2,1-3H3/t11-,12-,13?,14-,15-,16-,17+/m1/s1
SMILES Code: C[C@@]12C(O)[C@@H](O)[C@H]([C@@]23CO3)O[C@]4([H])C=C(C)CC[C@]14COC(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 324.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Lee DH, Park T, Kim HW. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54. PubMed PMID: 16595895.
2: Razzazi-Fazeli E, Rabus B, Cecon B, Böhm J. Simultaneous quantification of A-trichothecene mycotoxins in grains using liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry. J Chromatogr A. 2002 Aug 30;968(1-2):129-42. PubMed PMID: 12236496.
3: Nielsen KF, Thrane U. Fast methods for screening of trichothecenes in fungal cultures using gas chromatography-tandem mass spectrometry. J Chromatogr A. 2001 Sep 21;929(1-2):75-87. PubMed PMID: 11594405.
4: Klaffer U, Märtlbauer E, Terplan G. Development of a sensitive enzyme-linked immunosorbent assay for the detection of diacetoxyscirpenol. Int J Food Microbiol. 1988 Feb;6(1):9-17. PubMed PMID: 3079464.
5: Ikawa M, Carr C, Tatsuno T. Trichothecene structure and toxicity to the green alga Chlorella pyrenoidosa. Toxicon. 1985;23(3):535-7. PubMed PMID: 4024150.
6: Claridge CA, Bradner WT, Schmitz H. Antitumor activity of 15-acetoxyscirpen-3,4-diol. J Antibiot (Tokyo). 1978 May;31(5):485-6. PubMed PMID: 670090.
