SSE15206
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407940

CAS#: 1370046-40-4

Description: SSE15206 is a microtubule depolymerizing agent that overcomes multidrug resistance. SSE15206 has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin as shown by docking and competition studies..


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 4250
Size
Price

50mg
USD 250
500mg
USD 1450
5g
USD 6950
Size
Price

100mg
USD 450
1g
USD 2450

SSE15206, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407940
Name: SSE15206
CAS#: 1370046-40-4
Chemical Formula: C19H21N3O3S
Exact Mass: 371.1304
Molecular Weight: 371.455
Elemental Analysis: C, 61.44; H, 5.70; N, 11.31; O, 12.92; S, 8.63


Synonym: SSE15206; SSE-15206; SSE 15206;

IUPAC/Chemical Name: 4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide

InChi Key: GONIBFCARADPAC-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N3O3S/c1-23-16-9-13(10-17(24-2)18(16)25-3)15-11-14(21-22(15)19(20)26)12-7-5-4-6-8-12/h4-10,15H,11H2,1-3H3,(H2,20,26)

SMILES Code: S=C(N1N=C(C2=CC=CC=C2)CC1C3=CC(OC)=C(OC)C(OC)=C3)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Manzoor S, Bilal A, Khan S, Ullah R, Iftikhar S, Emwas AH, Alazmi M, Gao X,
Jawaid A, Saleem RSZ, Faisal A. Author Correction: Identification and
characterization of SSE15206, a microtubule depolymerizing agent that overcomes
multidrug resistance. Sci Rep. 2018 Apr 18;8(1):6427. doi:
10.1038/s41598-018-24114-7. PubMed PMID: 29666376; PubMed Central PMCID:
PMC5904161.

2: Manzoor S, Bilal A, Khan S, Ullah R, Iftikhar S, Emwas AH, Alazmi M, Gao X,
Jawaid A, Saleem RSZ, Faisal A. Identification and characterization of SSE15206,
a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep.
2018 Feb 19;8(1):3305. doi: 10.1038/s41598-018-21642-0. Erratum in: Sci Rep. 2018
Apr 18;8(1):6427. PubMed PMID: 29459693; PubMed Central PMCID: PMC5818492.