ONO-8590580
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MedKoo CAT#: 564301

CAS#: 1802661-73-9

Description: ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models.


Price and Availability

Size
Price

200mg
USD 2150
2g
USD 6950
Size
Price

500mg
USD 2950
5g
USD 13650
Size
Price

1g
USD 3950

ONO-8590580, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564301
Name: ONO-8590580
CAS#: 1802661-73-9
Chemical Formula: C21H21FN6
Exact Mass: 376.1812
Molecular Weight: 376.44
Elemental Analysis: C, 67.00; H, 5.62; F, 5.05; N, 22.33


Synonym: ONO8590580; ONO 8590580; ONO-8590580

IUPAC/Chemical Name: 1-(Cyclopropylmethyl)-5-fluoro-4-methyl-N-(5-(1-methyl-1H-imidazol-4-yl)pyridin-2-yl)-1H-benzo[d]imidazol-6-amine

InChi Key: INGJMHPGMVUEKY-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21FN6/c1-13-20(22)16(7-18-21(13)25-12-28(18)9-14-3-4-14)26-19-6-5-15(8-23-19)17-10-27(2)11-24-17/h5-8,10-12,14H,3-4,9H2,1-2H3,(H,23,26)

SMILES Code: CN1C=C(C2=CN=C(NC3=C(F)C(C)=C4C(N(CC5CC5)C=N4)=C3)C=C2)N=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Kawaharada S, Nakanishi M, Nakanishi N, Hazama K, Higashino M, Yasuhiro T, Lewis A, Clark GS, Chambers MS, Maidment SA, Katsumata S, Kaneko S. ONO-8590580, a Novel GABA(A)α5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models. J Pharmacol Exp Ther. 2018 Jul;366(1):58-65. doi: 10.1124/jpet.117.247627. Epub 2018 Apr 19. PubMed PMID: 29674331.